肥胖导致的T细胞代谢障碍及相关疾病的研究进展

Research progress of obesity associated T cell metabolic disorder and related diseases

肥胖会增加感染性疾病与肿瘤的发病风险。研究发现,肥胖可能从影响T细胞脂类和糖类代谢、促进炎性因子释放和T细胞衰老等方面造成T细胞代谢障碍,进而使机体发生感染后病死率增加,也是导致这些疾病流行的重要危险因素。肥胖和肿瘤预后不良相关,是其影响免疫代谢和促炎性作用的多因素综合结果。该文综述了肥胖对T淋巴细胞代谢障碍的研究进展,及T细胞代谢障碍在感染性疾病和肿瘤中的作用与治疗前景。

Obesity increases the risk of infectious and neoplastic diseases.Studies have found that obesity may cause T cell metabolism disorders by affecting T cell lipid and carbohydrate metabolisms,promoting the release of inflammatory factors,and T cell aging,thereby increasing the mortality upon infection.Obesity is also an important risk factor associated with the prevalence of diseases.Obesity is associated with poor prognosis of neoplastic diseases,which is the combined effect of multiple factors affecting immune metabolism and inflammation.This review summarizes the research progress on T lymphocyte metabolism disorders caused by obesity and the role of T lymphocyte metabolism disorders in infectious and neoplastic diseases and treatment prospects.