双歧杆菌四联活菌片联合地衣芽孢杆菌治疗慢性腹泻疗效及用药安全性评价

Evaluation of Efficacy and Safety of Bifidobacteria Quadruple Viable Tablets Combined with Bacillus Licheniformis in the Treatment of Chronic Diarrhea

目的分析双歧杆菌四联活菌片联合地衣芽孢杆菌治疗慢性腹泻的疗效及用药安全性。方法选择2020年10月—2023年10月天津市公安医院收治的85例慢性腹泻患者作为研究对象,随机分为单一组43例和联合组42例,单一组采用双歧杆菌四联活菌片治疗,联合组采用双歧杆菌四联活菌片联合地衣芽孢杆菌治疗。比较两组治疗前后菌种检测数量,比较两组疗效、止泻时间、粪便特性及不良反应。结果联合组临床总有效率高于单一组,差异有统计学意义(P<0.05)。治疗前,两组菌种检测数量进行比较,差异无统计学意义(P>0.05);治疗后,两组菌种检测数量均改善且联合组改善优于单一组,差异有统计学意义(P<0.05)。联合组止泻时间、粪便成形率均优于单一组,差异有统计学意义(P<0.05)。两组不良反应发生率进行比较,差异无统计学意义(P>0.05)。结论双歧杆菌四联活菌片联合地衣芽孢杆菌治疗慢性腹泻疗效确切,能有效调节肠道菌群,缩短止泻时间,且具有较高的安全性。

Objective Analyze the efficacy of Bifidobacterium bifidum quadruple viable tablets combined with Bacillus licheniformis in the treatment of chronic diarrhea and evaluate the safety of medication.Methods A total of 85 cases of chronic diarrhea patients admitted to Tianjin Public Security Hospital from October 2020 to October 2023 were selected as the study subjects and randomly divided into 43 cases in the single group and 42 cases in the combined group.The single group was treated with Bifidobacterium bifidum quadruple viable tablets,and the combined group was treated with Bifidobacterium bifidum quadruple viable tablets combined with Bacillus licheniformis.The number of strains detection before and after the treatment,clinical efficacy,antidiarrheal time,fecal characteristics and adverse reactions were compared between the two groups.Results The total clinical effectiveness rate of the combined group was significantly higher than that of the single group(P<0.05).Before treatment,the number of strains detection in the two groups showed no significant difference(P>0.05).After treatment,the number of strains detection in the two groups improved,and the improvement in the combined group was significantly better than that in the single group(P<0.05).The antidiarrheal time and fecal formation rate of the combined group were significantly better than that of the single group(P<0.05).There was no significant difference in the incidence of adverse reactions between two groups(P>0.05).Conclusion Bifidobacterium bifidum quadruple viable bacterial tablets combined with Bacillus licheniformis has definite efficacy in the treatment of chronic diarrhea,which can effectively regulate the intestinal flora,shorten the time to stop diarrhea,and has a high degree of safety.