倍他司汀联合地塞米松治疗突发性聋患者的效果

Effects of Betahistine combined with Dexamethasone in treatment of patients with sudden deafness

目的:观察倍他司汀联合地塞米松治疗突发性聋患者的效果。方法:回顾性分析2022年3月至2023年8月该院收治的64例突发性聋患者的临床资料,根据治疗方法不同将其分为对照组和观察组各32例。两组均予以常规治疗,在此基础上,对照组给予地塞米松治疗,观察组在对照组基础上联合倍他司汀治疗。比较两组临床疗效,治疗前后血液流变学指标[血浆黏度(PV)、全血高切黏度(HBV)、全血低切黏度(LBV)]水平、听力阈值、凝血功能指标[纤维蛋白原(FIB)、凝血酶原时间(PT)]水平,以及不良反应发生率。结果:观察组治疗总有效率为96.88%(31/32),高于对照组的75.00%(24/32),差异有统计学意义(P<0.05);治疗后,两组LBV、HBV、PV水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组500、1000、2000 Hz频率点的听力阈值均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组FIB水平均低于治疗前,且观察组低于对照组,两组PT均长于治疗前,且观察组长于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:倍他司汀联合地塞米松治疗突发性聋患者可提高治疗总有效率,改善凝血功能指标水平,以及降低血液流变学指标水平和听力阈值的效果优于单纯地塞米松治疗。

Objective:To observe effects of Betahistine combined with Dexamethasone in treatment of patients with sudden deafness.Methods:The clinical data of 64 patients with sudden deafness admitted to this hospital from March 2022 to August 2023 were retrospectively analyzed.According to different treatment methods,they were divided into control group and observation group,32 cases in each group.Both groups were given routine treatment.On this basis,the control group was treated with Dexamethasone,while the observation group was treated with Betahistine on the basis of that of the control group.The clinical efficacy,the levels of hemorheology indexes[plasma viscosity(PV),high shear whole blood viscosity(HBV),low shear whole blood viscosity(LBV)],hearing threshold and coagulation function indexes[fibrinogen(FIB),prothrombin time(PT)]before and after the treatment,and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of the observation group was 96.88%(31/32),which was higher than that of the control group 75.00%(24/32),and the difference was statistically significant(P<0.05).After the treatment,the levels of LBV,HBV and PV in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The hearing thresholds at 500,1000 and 2000 Hz in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).The FIB levels of the two groups were lower than those before the treatment,and that in the observation group was lower than that in the control group;the PT of the two groups were longer than those before the treatment,and that in the observation group was longer than that in the control group;and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:Betahistine combined with Dexamethasone in the treatment of the patients with sudden deafness can improve the total effective rate of treatment,improve the levels of coagulation function indexes,and reduce the levels of hemorheology indexes and hearing threshold.Moreover,it is superior to simple Dexamethasone treatment.