两面针药理作用及质量标志物预测分析研究进展

Research Progress in Pharmacological Effects of Zanthoxyli Radix and Prediction and Analysis of Q-markers

两面针药用历史悠久,《神农本草经》以蔓椒之名载之。现代药理研究表明,两面针具有抗肿瘤、抗菌、抗氧化、止血等作用。本文结合功能主治,对两面针药理作用进行综述,并依据中药质量标志物(Q-marker)的基本要求,从其基原植物亲缘学和化学成分特有性、化学成分与药效相关性,以及化学成分可测性等角度对两面针Q-marker进行预测分析,提出将生物碱类、黄酮类、木脂素类作为两面针总分类Q-marker筛选对象,将氯化两面针碱、白屈菜红碱、木兰花碱、茵芋碱、香叶木苷、橙皮苷、L-芝麻脂素、L-细辛脂素等化学成分作为Q-marker的候选成分,为两面针药材的质量标准进一步研究提供参考。

The medicinal history of Zanthoxyli Radix is long,and it is recorded in the Shen Nong Ben Cao Jing under the name of Manjiao.Modern pharmacological research has proven that Zanthoxyli Radix has anti-tumor,antibacterial,antioxidant,and hemostatic effects.This article reviewed the pharmacological effects of Zanthoxyli Radix based on its functional indications.Based on the basic requirements of TCM quality markers(Q-markers),this article predicted and analyzed the Q-markers of Zanthoxyli Radix from the perspectives of plant phylogeny and chemical component specificity,chemical component and pharmacological correlation,and chemical component testability.It is proposed to select alkaloids,flavonoids,and lignans as the Q-markers for the general classification of Zanthoxyli Radix.The candidate components for Q-marker were identified,including chloramphenicol,white croaker alkaloid,magnolian alkaloid,taro alkaloid,vanillin,hesperidin,L-sesamin and L-asarone,providing a reference for further research on the quality standards of Zanthoxyli Radix.