不同体质颈动脉粥样硬化患者总胆汁酸特点

The characteristics of total bile acid in carotid atherosclerosis patients with different traditional Chinese medicine constitution

目的探究不同体质颈动脉粥样硬化(carotid atherosclerosis,CAS)患者的总胆汁酸差异。方法选取2022年12月至2023年5月于泰安市立医院就诊的CAS患者,收集患者的临床资料并进行中医体质辨识,分析不同体质患者间血清总胆汁酸的差异。结果共纳入212例CAS患者,其中偏颇体质151例,排名前3位的分别为阳虚质49例(23.1%)、气郁质25例(11.8%)、血瘀质19例(9.0%)。阴虚质CAS患者的体质量指数显著低于其他体质患者(P<0.05),阳虚质CAS患者的血清总胆汁酸水平显著高于平和质、气郁质、血瘀质、痰湿质、湿热质患者(P<0.05)。结论不同体质CAS患者的血清总胆汁酸存在差异,其中阳虚质与总胆汁酸代谢关系密切。

Objective To explore the differences of total bile acid in carotid atherosclerosis(CAS)patients with different traditional Chinese medicine(TCM)constitution.Methods CAS patients who were treated in Tai’an Municipal Hospital from December 2022 to May 2023 were selected,clinical data of patients were collected and TCM constitution was identified,and differences in serum total bile acid among patients with different TCM constitutions were analyzed.Results A total of 212 CAS patients were included,including 151 patients with biased constitution.The top 3 biased constitution included yang-deficiency constitution(49 cases,23.1%),qi-depression constitution(25 cases,11.8%),blood-stasis constitution(19 cases,9.0%).The body mass index of patients with yin-deficiency constitution was significantly lower than that of other patients(P<0.05).The total bile acid level of patients with yang-deficiency constitution was significantly higher than that of patients with normal constitution,qi-depression constitution,blood-stasis constitution,phlegm-dampness constitution,humid heat constitution(P<0.05).Conclusion There are differences of total bile acid in CAS patients with different TCM constitution,and yang-deficiency constitution is closely related to total bile acid metabolism.