通腑醒神汤对高血压脑出血患者微创手术后神经功能及炎性因子的影响

Effect of Tongfu Xingshen Decoction on Neurological Function and Inflammatory Factors in Patients with Hypertensive Cerebral Hemorrhage after Minimally Invasive Surgery

目的探究在高血压脑出血微创术后采取通腑醒神汤治疗的效果。方法选取2021年2月—2023年2月曲阜市中医院收治的88例高血压脑出血患者为研究对象,按术后用药方法的不同分为对照组、观察组,各44例。两组患者均行微创手术,对照组在术后使用依达拉奉注射液治疗,观察组在对照组基础上结合通腑醒神汤治疗。对比两组治疗总有效率、美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale,NIHSS)评分、巴塞尔指数(Barthel Index,BI)、炎性因子水平及不良反应发生情况。结果对照组治疗总有效率为81.82%(36/44),低于观察组的95.45%(42/44),差异有统计学意义(χ^(2)=4.062,P<0.05)。治疗后,对照组NIHSS评分高于观察组,BI评分低于观察组,差异有统计学意义(P均<0.05)。对照组C反应蛋白、肿瘤坏死因子-α、白细胞介素-6水平均高于观察组,差异有统计学意义(P均<0.05)。对照组不良反应总发生率高于观察组,差异有统计学意义(P<0.05)。结论接受微创手术的高血压脑出血患者服用通腑醒神汤具有明显的治疗效果,能够有效促进神经系统恢复,改善炎症反应,且不良反应较少。

Objective To explore the effect of Tongfu Xingshen Decoction after minimally invasive surgery for hypertensive cerebral hemorrhage.Methods A total of 88 patients with hypertensive cerebral hemorrhage admitted to Qufu Hospital of Traditional Chinese Medicine from February 2021 to February 2023 were selected as the study objects and divided into control group and observation group according to different postoperative medication methods,with 44 cases in each group.Both groups were treated with minimally invasive surgery.The control group was treated with edaravone injection after operation,and the observation group was treated with Tongfu Xingshen Decoction on the basis of control group.The total effective rate,score of National Institutes of Health Stroke Scale(NIHSS),Barthel Index(BI),inflammatory factors and adverse reactions were compared between the two groups.Results The total effective rate of the control group was 81.82%(36/44),which was lower than 95.45%(42/44)of the observation group,and the difference was statistically significant(χ^(2)=4.062,P<0.05).After treatment,the NIHSS score of the control group was higher than that of the observation group,and the BI score was lower than that of the observation group,and the differences were statistically significant(both P<0.05).The levels of C-reactive protein,tumor necrosis factor-αand interleukin-6 in the control group were higher than those in the observation group,and the differences were statistically significant(all P<0.05).The total incidence of adverse reactions in the control group was higher than that in the observation group,and the difference was statistically significant(P<0.05).Conclusion Tongfu Xingshen Decoction has obvious therapeutic effect in patients after minimally invasive surgery for hypertensive cerebral hemorrhage,which can effectively the promote recovery of the nervous system,improve the inflammatory response,and the occurrence of adverse reactions is less.