美托洛尔联合厄贝沙坦治疗老年高血压的疗效及不良反应分析

Analysis of efficacy and adverse reactions of metoprolol combined with irbesartan in the treatment of senile hypertension

目的 分析老年高血压患者使用美托洛尔联合厄贝沙坦进行治疗的效果及不良反应。方法 68例老年高血压患者作为研究对象,在随机抽样法方式下将患者分成常规组及研究组,每组34例。常规组患者使用美托洛尔单独治疗,研究组患者使用美托洛尔联合厄贝沙坦疗治疗。比较两组治疗效果、血压指标、心率、不良反应发生情况、生活质量评分、内分泌相关指标。结果 研究组治疗总有效率94.12%高于常规组的70.59%,具有统计学价值(P<0.05)。治疗后,研究组舒张压(77.51±8.31)mm Hg(1 mm Hg=0.133 kPa)、收缩压(125.54±11.26)mm Hg、心率(71.36±6.25)次/min均低于常规组的(86.99±10.74)mm Hg、(138.74±11.65)mm Hg、(80.47±10.53)次/min,具有统计学价值(P<0.05)。治疗后,研究组生理功能、生理职能、躯体疼痛、总体健康、精神健康、社会功能、活力、情感职能评分分别为(89.98±14.32)、(90.97±10.87)、(86.89±10.83)、(91.78±14.37)、(82.21±16.13)、(89.89±10.94)、(88.34±14.38)、(92.25±11.34)分,均高于常规组的(74.64±13.78)、(85.01±11.21)、(80.81±10.46)、(85.05±13.22)、(74.01±15.23)、(81.20±10.68)、(81.58±13.10)、(83.89±11.13)分,具有统计学价值(P<0.05)。两组不良反应发生率比较,没有统计学意义(P>0.05)。治疗后,研究组空腹血糖(5.46±0.51)mmol/L、肌酐(97.02±7.14)μmol/L、尿素氮(6.01±0.47)mmol/L、总胆固醇(5.52±1.75)mmol/L、甘油三酯(1.75±1.21)mmol/L均低于参照组的(5.92±0.43)mmol/L、(107.64±9.85)μmol/L、(7.55±0.74)mmol/L、(6.78±1.36)mmol/L、(2.49±1.18)mmol/L,具有统计学价值(P<0.05)。结论 为老年高血压患者使用美托洛尔联合厄贝沙坦进行治疗,效果显著,临床应用价值较高。

Objective To analyze the effect and adverse reactions of metoprolol combined with irbesartan in the treatment of senile hypertension.Methods 68 elderly patients with hypertension were divided into a conventional group and a study group by random sampling method,with 34 cases in each group.Patients in the conventional group were treated with metoprolol alone,while patients in the study group were treated with metoprolol combined with irbesartan.The therapeutic effect,blood pressure,heart rate,occurrence of adverse reaction,quality of life score and endocrine related indicators were compared between the two groups.Results The total effective rate of the study group was 94.12%,which was higher than 70.59%of the conventional group,and there was statistical value(P<0.05).After treatment,the study group had diastolic blood pressure of(77.51±8.31)mm Hg(1 mm Hg=0.133 kPa),systolic blood pressure of(125.54±11.26)mm Hg,and heart rate of(71.36±6.25)beats/min,which were lower than(86.99±10.74)mm Hg,(138.74±11.65)mm Hg,and(80.47±10.53)beats/min in the conventional group,and there was statistical value(P<0.05).After treatment,the scores of physical function,role-physical,bodily pain,general health,mental health,social function,vitality,and role-emotional of the study group were(89.98±14.32),(90.97±10.87),(86.89±10.83),(91.78±14.37),(82.21±16.13)and(89.89±10.94),(88.34±14.38),and(92.25±11.34)points,which were higher than(74.64±13.78),(85.01±11.21),(80.81±10.46),(85.05±13.22),(74.01±15.23),(81.20±10.68),(81.58±13.10),and(83.89±11.13)points of the conventional group.There was statistical value(P<0.05).There was no statistical significance in the incidence of adverse reactions between the two groups(P>0.05).After treatment,the study group had fasting blood glucose of(5.46±0.51)mmol/L,creatinine of(97.02±7.14)μmol/L,urea nitrogen of(6.01±0.47)mmol/L,total cholesterol of(5.52±1.75)mmol/L,and triglyceride of(1.75±1.21)mmol/L,which were lower than(5.92±0.43)mmol/L,(107.64±9.85)μmol/L,(7.55±0.74)mmol/L,(6.78±1.36)mmol/L,and(2.49±1.18)mmol/L of the conventional group.There was statistical value(P<0.05).Conclusion Metoprolol combined with irbesartan has significant effect and high clinical application value in the treatment of elderly patients with hypertension.