一种改善糖尿病肾病的新型化合物3-(3,4-二羟基苯基)-2(1H)-喹喔啉酮

A Novel Compound of 3-(3,4-dihydroxyphenyl)-2(1H)-Quinoxalinone Ameliorating Diabetic Nephropathy with Hypoglycemia and Antioxidant Effects

目的:糖尿病肾病(Diabetes nephropathy,DN)是导致终末期肾病的主要原因,也是糖尿病最顽固的并发症之一。活性氧(reactive oxygen species,ROS)累积导致的氧化应激促进DN的发展,因此,清除ROS是预防和治疗DN的关键方法。方法:制备了3-芳基喹喔啉酮衍生物。通过测量糖尿病模型鼠的尿蛋白水平、丙二醛(Malondialdehyde,MDA)水平和肾脏谷胱甘肽(Glutathione,GSH)水平,测定该化合物DN病症改善效果。结果:3-(3,4-二羟基苯基)-2(1H)-喹喔啉酮可降低小鼠的尿蛋白、MDA水平,增加肾脏GSH水平,证实其显著的抗氧化作用,改善蛋白尿,降低氧化应激水平,缓解糖尿病肾病病理症状。结论:以上结果表明该化合物在改善DN引起的肾损伤中具有潜在作用。

Objective:diabetes nephropathy(DN)is the main cause of end-stage renal disease and one of the most intractable complications of diabetes.The accumulation of reactive oxygen species(ROS)leads to oxidative stress that promotes the development of DN:Therefore,clearing ROS is a key method for preventing and treating DN.Method:3-aryl quinoxalone derivatives were prepared.By measuring urine protein,malondialdehyde level,renal glutathione level and superoxide dismutase activity,the improvement effect of the compound on DN was determined.Results:3-(3,4-dihydroxyphenyl)-2(1H)-quinoxalinone can reduce the levels of urine protein,MDA,increase the level of GSH and SOD activity in the kidney of diabetes nephropathy mice,which confirms its significant antioxidant effect,improving proteinuria.Conclusion:The above results indicate that this compound has a potential role in improving kidney damage caused by DN.