Wnt2/β-catenin在胎盘植入性疾病孕妇外周血及脐血中的表达及意义

Expression and the significance of the secretory glycoprotein 2 and β-catenin in the peripheral blood and in the umbilical cord blood of pregnant women with placenta accreta

目的:探讨分泌型糖蛋白2(Wnt2)、β-连环蛋白(β-catenin)在胎盘植入性疾病孕妇外周血及脐血中的表达及意义。方法:选择2020年5月-2023月4月本院收治的156例胎盘植入性疾病孕妇临床资料,包括胎盘粘连(胎盘粘连组78例)与胎盘植入(胎盘植入组78例),同期接受剖宫产手术的健康孕妇80例为对照组。纳入对象入院后均检测外周血及脐血中Wnt2、β-catenin水平并比较。采用Spearman相关分析探讨外周血及脐血中Wnt2、β-catenin与胎盘植入超声评分量表评分关系,受试者工作特征(ROC)曲线评估孕妇外周血中Wnt2、β-catenin对胎盘植入性疾病的预测价值。结果:对照组、胎盘粘连组、胎盘植入组孕妇外周血及脐血中Wnt2、β-catenin水平依次升高(均P<0.05)。Spearman相关分析显示,胎盘植入性疾病孕妇外周血、脐血中Wnt2与β-catenin均呈正相关,Wnt2、β-catenin与胎盘植入超声评分量表评分均呈正相关(均P<0.05)。ROC曲线分析显示,Wnt2、β-catenin及两项联合预测胎盘植入性疾病发生的曲线下面积分别为0.830、0.859、0.905。结论:胎盘植入孕妇外周血及脐血中Wnt2、β-catenin水平异常升高,其水平升高与孕妇胎盘植入发生有一定相关性,对胎盘植入发生有较高评估价值。

Objective:To investigate the expression and the significance of the secretory glycoprotein 2(Wnt2)and β-catenin in the peripheral blood and in the umbilical cord blood of pregnant women with placenta accreta.Methods:The clinical data of 156 pregnant women with placenta accreta admitted to our hospital from May 2020 to April 2023 were selected in this study,including 78 cases with placenta accreta in group A and 78 cases with placenta implantation in group B.80healthy pregnant women who underwent cesarean section were selected in group C.The levels of Wnt2 and β-catenin of the women in the peripheral blood and in the umbilical cord blood were detected after admission and were compared among the three groups.Spearman correlation analysis was used to explore the correlation between the levels of Wnt2 and β-catenin of the pregnant women in the peripheral blood and in the umbilical cord blood and their placenta accreta ultrasound score.Receiver operating characteristic(ROC)curve was used to evaluate the predictive value of the levels of Wnt2 and β-catenin in the peripheral blood of the pregnant women and their placenta accreta.Results:The levels of Wnt2 and β-catenin in the peripheral blood and in the umbilical cord blood of the women in group C,in group A and in group B had increased gradually(all P<0.05).Spearman correlation analysis showed that the Wnt2 level in the peripheral blood and in the umbilical cord blood of the women with placenta implantation was positively correlated with theirβ-catenin level,and the levels of Wnt2 and β-catenin of the women with placenta implantation were positively correlated with their placenta accreta ultrasound rating scale score(all P<0.05).ROC curve analysis showed that the area under the curve of the Wnt2 level,the β-catenin level or the combination of the Wnt2 and β-catenin levels of the pregnant women for predicting their placenta accreta was 0.830,0.859 or 0.905,respectively.Conclusion:The levels of Wnt2 and β-catenin in the peripheral blood and the umbilical blood of the pregnant women with placenta implantation abnormally,and which are correlated with their degree of the placenta implantation and have higher evaluation value for the placenta implantation of the pregnant women.