骨刺宁胶囊联合骨肽注射液治疗骨质增生症的临床研究

Clinical study on Gucining Capsules combined with Ossotide Injection in treatment of osteoproliferation

目的探究骨刺宁胶囊联合骨肽注射液治疗骨质增生症的有效性与安全性。方法选取2017年11月—2018年11月新疆维吾尔自治区人民医院收诊的骨质增生症患者133例,随机分成对照组(66例)和治疗组(67例)。对照组患者静脉滴注骨肽注射液,10 mL加入200 mL生理盐水,1次/d;治疗组患者在对照组基础上口服骨刺宁胶囊,4粒/次,3次/d。两组患者均连续治疗2个月。观察两组患者临床疗效,同时比较治疗前后两组患者VAS、QOL-30和Oswestry评分以及血清TGF-β1、强啡肽和硬骨素水平。结果治疗后,对照组临床有效率为86.36%,显著低于治疗组的97.01%,两组比较差异具有统计学意义(P<0.05)。治疗后,两组患者VAS评分和Oswestry功能障碍指数评分均显著降低(P<0.05),QOL-30评分显著升高(P<0.05),且治疗组患者这些评分明显好于对照组(P<0.05)。治疗后,两组患者血清TGF-β1、强啡肽和硬骨素水平均显著升高(P<0.05),且治疗组患者血清TGF-β1、强啡肽和硬骨素水平高于对照组(P<0.05)。结论骨刺宁胶囊联合骨肽注射液治疗骨质增生症疗效显著,能够显著改善患者的生活质量和疼痛水平。

Objective To investigate the efficacy and safety of Gucining Capsules combined with Ossotide Injection in treatment of osteoproliferation.Methods Patients(133 cases)with osteoproliferation in People’s Hospital of Xinjiang Uygur Autonomous Region from November 2017 to November 2018 were randomly divided into control(66 cases)and treatment(67 cases)groups.Patients in the control group were iv administered with Ossotide Injection,10 mL added into 200 mL normal saline,once daily.Patients in the treatment group were po administered with Gucining Capsules on the basis of the control group,4 grains/time,three times daily.Patients in two groups were treated for 2 months.After treatment,the clinical efficacy was evaluated,and the VAS,QOL-30 and Oswestry dysfunction index scores,the serum TGF-β1,dynorphin and sclerostin levels in two groups before and after treatment were compared.Results After treatment,the clinical efficacy in the control group was 86.36%,which was significantly lower than 97.01%in the treatment group,and there were differences between two groups(P<0.05).After treatment,the VAS and Oswestry dysfunction index scores in two groups were significantly decreased(P<0.05),but QOL-30 scores were significantly increased(P<0.05),and these scores in the treatment group were significantly better than those in the control group(P<0.05).After treatment,the serum TGF-β1,dynorphin and sclerostin levels in two groups were significantly increased(P<0.05),and these indexes in the treatment group were significantly higher than those in the control group(P<0.05).Conclusion Gucining Capsules combined with Ossotide Injection is effective in treatment of osteoproliferation,and can significantly improve the quality of life and pain level of patients.