前列腺癌上皮间质转化与炎症之间的关系

Relationship between epithelial stromal transformation and inflammation in prostate cancer

目的探讨前列腺癌患者上皮间质转化(EMT)与组织炎症之间的关系。方法回顾性分析于我院就诊的25例前列腺癌(PCa组)及30例慢性前列腺炎合并前列腺癌(合并组)患者的临床资料,比较两组患者前列腺特异抗原(PSA)、Gleason评分和EMT的情况,利用酶联免疫吸附实验检测上皮型钙黏附蛋白(E-cadherin)、β-链蛋白(β-catenin)、波形蛋白(Vimentin)在两组患者中的表达情况。结果前列腺癌患合并炎症的患者前列腺特异抗原(PSA)、Gleason评分和转移率均显著高于前列腺患者(P<0.05);ELISA结果显示前列腺癌患合并炎症的患者上皮型钙黏附蛋白(E-cadherin)、β-链蛋白(β-catenin)均显著低于前列腺患者(P<0.05);前列腺癌患合并炎症的患者波形蛋白(Vimentin)均显著高于前列腺患者(P<0.05)。结论慢性前列腺炎对前列腺癌PSA、Gleason评分和转移率均有显著的影响,并促进前列腺癌EMT的发生。

Objective To analyze the relationship between epithelial interstitial transformation(EMT) and tissue inflammation in patients with prostate cancer. Methods The clinical data of 25 patients with prostate cancer and 30 patients with chronic prostatitis combined with prostate cancer who were treated in our hospital from retrospectively analyzed(PSA), Gleason score and EMT were compared between the two groups. E-cadherin, β-catenin and Vimentin were detected by enzyme-linked immunosorbent assay in both groups. Results Prostate specific antigen(PSA), Gleason score and metastasis rate were significantly higher in patients with prostate cancer than in prostate patients(P<0.05). ELISA results showed that epithelial-type cadherin E(P<0.05). The expression of Vimentin in patients with prostate cancer was significantly higher than that in patients with prostate cancer(P<0.05). The expression of β-catenin was significantly lower than that of prostatic patients(P<0.05). Conclusion Chronic prostatitis that there were significant effect on prostate cancer PSA, Gleason score and metastasis rate, and promote the occurrence of prostate cancer EMT.