大肠癌血管内皮生长因子与雌激素受体的表达及临床意义

Expression and Clinical Significance of VEGF and ER in Colorectal Cancer

目的 探讨VEGF、ER在大肠癌组织中的表达和临床意义。方法 应用免疫组织化学SP法研究 45例大肠癌组织中VEGF、ER的表达。结果 45例大肠癌中VEGF阳性表达率显著高于ER(χ2 =9.3 9,P <0 .0 1) ,在淋巴结转移组VEGF、ER表达分别为72 .2 %和 16.7% ,在无淋巴结转移组分别为 2 5 .9% (χ2 =9.3 8,P <0 .0 1)和 48.1% (χ2 =4.67,P <0 .0 5 ) ;在分化好组VEGF、ER表达分别为 5 6.3 %和 68.8% ,而分化差组分别为 3 7.9% (χ2 =1.40 ,P <0 .0 5 )和 17.2 % (χ2 =11.94,P <0 .0 1)。ER的表达与临床病理分期 (Dukes)差异有显著意义 (χ2 =8.15 ,P <0 .0 5 ) ,而VEGF则与之无关。结论 联合检测VEGF、ER的表达可作为大肠癌的预后指标 ,有助于对术后病人放、化疗或内分泌治疗的选择提供依据。

Objective To study the expression and clinical significance of vascular endothelial growht factor(VEGF) and estrogen receptor(ER) in colorectal cancer.Methods Immunohistochemical method(SP) was used to study the expression of VEGF and ER in 45 patients with colorectal cancer.Results The expression of VEGF were significantly higher than that of ER( χ 2=9.39,P <0.01).The expression of VEGF and ER in lymph node metastasis group was 72.2% and 16.7%,in non-metastasis group was 25.9%( χ 2=9.38,P <0.01) and 48.1%( χ 2=4.67,P <0.05);in differentiation better group was 56.3% and 68.8%,in differentiation worse group was 37.7%( χ 2=1.40,P<0.05) and 17.2%(χ 2=11.94,P<0.01) .ER was significantly different from clinical stage(Dukes stage, χ 2=8.15,P <0.05).Conclusions Examination of VEGF and ER expression can help select the patients who need chemotherapy,radiotherapy and endocrinetherapy,and may be as an indicator of prognosis.