兔腰神经根慢性炎性压迫后的行为学改变及超短波疗效观察

The effect of ultrashort wave diathermy on hyperalgesic behavior in rabbits with chronic inflammatory compression of lumbar nerve root

目的 通过观测模拟腰椎间盘突出动物模型的神经行为学改变 ,探讨超短波治疗对神经源性疼痛的疗效。方法 从椎间外孔塞入带髓核的有孔硅胶管 ,建立兔腰神经根慢性炎性压迫模型 ,测定动物的运动功能、热辐射刺激缩腿反应的潜伏期及电刺激痛阈值 ,观察空白对照组、损伤模型组和超短波治疗组在损伤后不同时间 (10d、3 0d和 90d)时的动物神经行为改变情况。结果 损伤模型组动物患肢的热痛阈和电痛阈发生改变 ,出现明显痛觉过敏的现象 ;超短波治疗组动物在损伤后 10d时患肢亦出现痛觉过敏的现象 ,但在损伤后 3 0d时已基本恢复正常。结论 兔腰神经根受到慢性压迫和自体髓核刺激后可引起痛觉过敏 ,而超短波治疗对兔腰神经根慢性炎性压迫后产生的神经源性疼痛具有积极的治疗作用。

Objective To investigate the therapeutic effect of ultrashort wave diathermy on neuropathic pain through a experimental model simulating lumbar disc herniation in rabbit. MethodsA silastic holey tube with nucleus pulposus was inserted into extra intervertebral foramina to produce chronic inflammatory compression on the lumbar nerve root of rabbit. The motor function,latency for thermal pain withdrawal and electrostimulation pain threshold in the affected hind limb of the rabbits were studied on 10th,30th and 90th days post-injury,and comparisons were conducted among sham-operation, experiment model and ultrashort wave diathermy groups. ResultsThe rabbits presented significant hyperalgesia behavior after injury, as compared with those in the sham-operation group. The phenomenon of hyperalgesia can be relieved by ultrashort wave diathermy, especially on 30th and 90th days post-injury. ConclusionThere were significant hyperalgesia behaviors after chronic compression and nucleus pulposus stimulation on lumbar nerve root in rabbits.The ultrashort wave diathermy played an important role in relieving the neuropathic pain produced by chronic inflammatory compression of lumbar nerve root.