子宫切除术与卵巢功能

Effect of Premenopausal Hysterectomy on Ovarian Function

目的了解切除子宫,保留双侧或一侧卵巢的妇女术后卵巢功能是否受影响。方法对521名患者进行问卷式回顾性调查,分析术时年龄、手术方式、手术范围、病种与卵巢功能的关系。同时对某一单位1600余名女职工进行正常人群的月经及绝经症状情况调查。结果正常人群组中有197名妇女出现潮热症状,平均年龄(46.87±4.22)岁;手术组患者中出现潮热症状者293名,手术时年龄(42.84±4.37)岁,术后出现潮热的时间是术后(1.99±2.40)年,平均年龄(44.64±4.31)岁,即子宫切除术后卵巢仅有不到2年的正常功能,而且比正常人群还提前两年出现潮热症状(P<0.01)。手术方式及病种与潮热症状的出现无关,手术范围与潮热症状的出现呈正相关(r=0.197,P<0.001)。结论保留卵巢的子宫切除术能影响卵巢功能,使之提前衰退。

Objective To investigate the influence of premenopausal hysterectomy on the function of the conserved ovaries.Methods A retrospective survey was conducte d by sending questionnaire to521cases of hysterectomized women(with the cons ervation one or two ovaries)for benign gynecological diseases and1600cases of normal controls(with contact uterus and bilateral ovaries).Age,type of o peration,diagnosis and the time of the onset of the menopausal syndrome were asked in the question-naire.Results The mean age of the onset of the hot flush (293cases)in the hysterectomized group was(44.64±4.31)years,wh ich was significantly lower than that of the normal group (46.87±4.2 2)years,197cases(P<0.01).The mean age of the above293women un dergoing hysterectomized was(42.84±4.37)years.The range of the oper ation was positive ly correlated with the time of the onset of the menopause sy ndrome.So there was only(1.99±2.40)-year interval between the hyster ectomy and the onset of the hot flush.Conclusion Hysterectomy with the conser vation of bilateral/unilateral ovaries may have some certain influence on ovari an function.