银杏达莫注射液对2型糖尿病脑梗塞患者CRP、IL-6及sICAM-1水平的影响

Effect of Ginkgo-Dipyidamolum Injection on CRP、IL-6 and sICAM-1 in the Patients with Type 2 Diabetic with Cerebral infraction

目的:观察银杏达莫注射液对2型糖尿病脑梗塞患者血液2型糖尿病脑梗塞的影响,探讨银杏达莫注射液治疗2型糖尿病脑梗塞的机制。方法:采用银杏达莫注射液治疗50例2型糖尿病脑梗塞患者,取常规西药组50例作为对比观察,于治疗前后检测患者血液中细胞因子CRP、IL-6及sICAM-1水平。结果:银杏达莫注射液治疗2型糖尿病脑梗塞总有效率92.0%,而对照组总有效率为76.0%,两组比较差异有显著性;治疗前银杏达莫注射液治疗组CRP、IL-6及sICAM-1水平与西医治疗对照组比较差异无显著性;治疗后两组CRP、IL-6及sICAM-1均显著降低,但银杏达莫注射液治疗组下降更为明显,与西医治疗组比较差异有显著性。结论:银杏达莫注射液结合西医治疗对2型糖尿病肾病有显著疗效,可能与银杏达莫注射液能调节炎性细胞因子的产生,抑制炎症反应有关。

Objective To observe the effect of Ginkgo-Dipyidamolum injection on CRP、IL-6 and sICAM-1 in the patients with Type 2 Diabetic with Cerebral infraction and to study the curing mechanism of Ginkgo-Dipyidamolum injection to diabetic nephropathy. Methods 50 patients with Type 2 Diabetic with Cerebral infraction were treated with Ginkgo-Dipyidamolum injection,and 50 Type 2 Diabetic with Cerebral infraction patients remedied routinely were taken as contrasts. The levels of CRP、IL-6 and sICAM-1 in the blood of patients were tested both before the treatment and after cure courses. Results The total utility rate( 92. 0%) of Ginkgo-Dipyidamolum injection to Type 2 Diabetic with Cerebral infraction was significantly higher than that of control group( 76. 0 %). After the treatment,the levels of CRP、IL-6 and sICAM-1 in the group treated with Ginkgo-Dipyidamolum injection were lower than that of control group. Conclusion There was a significant treatment effect of Ginkgo-Dipyidamolum injection on the patient with Type 2 Diabetic with Cerebral infraction. The curing mechanism of Ginkgo-Dipyidamolum injection to Type 2 Diabetic with Cerebral infraction may be this traditional Chinese medicine can regulate the production of inflammatory cytokins and can inhibit inflammatory reaction.