食管鳞癌组织中E-cadherin蛋白表达及对术后预后的影响

Impact of E-cadherin protein expression in esophageal squamous cell carcinoma tissue on postoperation prognosis

目的:探讨食管鳞癌组织中E-cadherin蛋白表达对术后预后的影响。方法:5 620例1985年至2016年间收集的食管鳞癌患者生物样本及临床病理信息均来自河南省食管癌重点开放实验室建立的50万例食管癌和贲门癌临床信息数据库,利用组织芯片和SP免疫组化法测定患者食管鳞癌组织中E-cadherin的表达。结果:男性患者中,分化程度低、淋巴结转移阳性、病理分期晚的患者E-cadherin表达强于分化程度高、淋巴结转移阴性、病理分期早者(P <0. 05)。女性患者中,淋巴结转移阳性、病理分期晚的患者E-cadherin表达强于淋巴结转移阴性、病理分期早者(P <0. 05)。Cox回归分析结果显示,E-cadherin阳性表达不是女性患者术后预后的独立影响因素(P=0. 089);但是男性患者的术后预后独立危险因素,HR(95%CI)为1. 126(1. 066～1. 189)。结论:癌组织中E-cadherin蛋白阳性表达是食管鳞癌男性患者术后预后的危险因素。

Aim: To investigate the effects of E-cadherin protein expression on survival of the patients with esophageal squamous cell carcinoma( ESCC). Methods: The biological samples and clinicopathological information of 5 620 patients with ESCC collected during 1985-2016 were derived from the clinical information database of 500 000 cases of esophageal and gastric cardia carcinoma of Henan key laboratory of esophageal cancer research. The expression of E-cadherin in ESCC tissue was determined by tissue microarray technology and SP immunohistochemical staining method. Results: The expression of E-cadherin was more in the female patients with lymph node metastasis and high pathological staging( P < 0. 05),which was higher in the male patients with low differentiation degree,lymph node metastasis and high pathological staging( P < 0. 05). The results of Cox regression showed that E-cadherin positive expression was the independent influencing factors of prognosis for the male patients( HR was 1. 126,95% CI was 1. 066-1. 189);but not for the female patients( P =0. 089). Conclusion: E-cadherin positive expression may be a risk factor for the prognosis of the male ESCC patients.