张培彤治疗胰腺癌的临床用药规律

Clinical Medication Rule of Zhang Peitong in the Treatment of Pancreatic Cancer

目的:分析张培彤治疗胰腺癌的临床用药规律并分析其学术思想。方法:收集张培彤治疗胰腺癌患者的电子处方,通过基于复杂网络分析和点式互信息方法的数据挖掘方法,分析临床常用中药、配伍药对及核心处方等用药规律。结果:147例胰腺癌患者总计就诊567次,有效中药处方567张,共计使用药物287味,使用频次共计10 476次。高频中药21味,占所有用药频次的63.5%;高频药对15组,临床常用核心处方为膈下逐瘀汤和六君二母汤。结论:张培彤临床治疗胰腺癌以扶正补虚固护中焦脾胃为主,以清热解毒、活血化瘀、消痰散结攻邪为辅,临床脾虚湿阻证为六君二母汤,气滞血瘀证为膈下逐瘀汤,其他证型辨证加减。

Objective:To analyze Zhang Peitong′s clinical medication rule in the treatment of pancreatic cancer and his academic thought.Methods:The electronic prescriptions of pancreatic cancer patients treated by Zhang Peitong were collected,and the data mining method based on complex network analysis and point mutual information method was used to analyze the rules of the clinical frequently-used herbs,compatibility of couplet medicines and the core prescription.Results:A total of 147 patients with pancreatic cancer were treated 567 times,and 567 effective prescriptions of Chinese medicine were used.A total of 287 kinds of Chinese medicine were used,and the frequency of use was 10 476 times.High-frequency Chinese medicine were 21 flavor,accounting for 63.5%of all medication frequency.High-frequency couplet medicines were 15 groups.Clinical core prescriptions were Gexia Zhuyu Decoction and Liujun Ermu Decoction.Conclusion:Zhang Peitong′s clinical treatment of pancreatic cancer is mainly to nourish the deficiency and strengthen the spleen and stomach,supplemented by clearing away heat and detoxification,activating blood circulation and removing blood stasis,eliminating phlegm and dispersing stagnation and attacking pathogens.The clinical syndrome of spleen deficiency and dampness is Liujun Ermu Decoction.Qi stagnation and blood stasis is Gexia Zhuyu Decoction.Other syndrome types are added or subtracted.