摘要
目的探讨乙型肝炎患者血清可溶性细胞间粘附分子 1(sICAM 1)水平与肝损害的关系。方法采用双抗体夹心ELISA法。检测 2 0例正常人和 6 7例HBV感染患者血清sICAM 1。结果轻、中、重度慢性乙型肝炎 (CH)患者及重型乙型肝炎 (SH)早、中、晚期患者血清sICAM 1水平 ,均显著高于正常人 ;CH患者肝功能越差、其血清sICAM 1水平越高 ;SH患者肝衰竭越重 ,其血清sICAM 1水平反而越低。HBeAg阳性或HBVDNA阳性的乙肝患者血清sICAM 1水平与HBeAg阴性和HBVDNA阴性的乙肝患者相比差异无显著性。结论在CH和SH早期 ,乙肝患者血清sICAM 1水平随着患者肝损害的加重而升高。重型肝炎患者血清sICAM 1水平随着患者肝衰竭的加重而降低 ,故sICAM
Objectives To explore the relationship between serum levels of soluble intercellular adhesion molecule 1(sICAM 1) and liver damage in patients with viral hepatitis B.Methods Serum levels of sICAM 1 were measured by double antibody sandwich ELISA technique in 20 healthy donors and 67 patients with HBV infection.Results The serum levels of sICAM 1 in patients with chronic hepatitis B(CH; mild, moderate and severe grades), and critical viral hepatitis B (SH) patients in their early, intermediate and late stages were all significantly higher than those of healthy controls. The worse the liver function in CH patients, the higher were serum levels of sICAM 1;the more severe the failure of liver function in SH patients, the lower would be their serum levels of sICAM 1. As compared with the serum levels of sICAM 1 in CH patients with negative HBeAg and HBV DNA, those in CH patients with positive HBeAg and HBV DNA revealed no significant difference. Conclusion The serum levels of sICAM 1 in the early stage of CH and SH increase gradually with the aggravation of live damage, whereas those in SH patients decrease when failure of their liver function becomes worse. Therefore, sICAM can be used as a clinical criterion for monitoring the severity of viral hepatitis B and degree of liver damage.
出处
《医学临床研究》
CAS
2003年第1期13-15,共3页
Journal of Clinical Research
基金
福建省科委资助课题 (99 Z 14 )
关键词
肝炎
乙型
血液
胞间粘附分子1
hepatitis B/BL
intercellular adhesion molecule-1/BL