地佐辛用于腹腔镜胆囊切除术患者内脏镇痛的临床研究

Research of the Treatment Effects on Patient's Visceral Pain by Dezocine in Laparoscopic Cholecystectomy

目的观察地佐辛用于腹腔镜胆囊切除术患者内脏镇痛的有效性和安全性。方法选择60例ASAⅠ~Ⅱ级择期腹腔镜胆囊切除术患者,随机分为2组,每组30例:Ⅰ组为对照组,于术中行胆囊切除,之后予以芬太尼2μg/kg静脉注射;Ⅱ组为试验组,于术中行胆囊切除,之后予以地佐辛0.1 mg/kg静脉注射。观察2组患者的苏醒时间、评估术后体表痛和内脏痛镇痛效果、舒适度及不良反应。结果两组患者苏醒时间无显著差异(P>0.05);两组患者术后体表痛镇痛效果均良好,无显著差异(P>0.05);Ⅱ组患者的内脏镇痛评分显著优于Ⅰ组(P<0.05);Ⅱ组患者的舒适度评分显著优于Ⅰ组(P<0.05);Ⅱ组患者的不良反应发生率显著低于Ⅰ组(P<0.05)。结论地佐辛可安全有效地用于腹腔镜胆囊切除术的内脏镇痛,不良反应发生率低,是较为理想的镇痛药。

Objective To observe the effectiveness and safety of dezocine in patients with visceral pain after laparoscopic cholecystectomy.Methods 60 patients with ASA Ⅰ ~ Ⅱ in laparoscopic cholecystectomy,randomly divided into 2 groups,30 cases each: group Ⅰ was the control group,and group Ⅱ as test group.2 μg /kg fentanyl was injected into the vein while the gallbladder was removed and then taken out from the cavity in group Ⅰ.And 0.1 mg /kg dezocine in group Ⅱ.The 2 groups were observed the recovery time,the analgesic effect of postoperative body surface pain and visceral pain,the degree of comfort,and the adverse reactions.Results The recovery times were no significant difference between the two groups( P > 0.05).The patients of two groups could have good analgesic effect of postoperative body surface pain.There were no significant difference( P > 0.05).The patients,visceral pain in group Ⅱ were significantly better than those in group Ⅰ( P < 0.05).The patients,comfort scores in group Ⅱ were significantly better than those in group Ⅰ( P < 0.05).The adverse reactions occurred in group Ⅱ was significantly lower than that in group Ⅰ( P< 0.05).Conclusions With low incidence of adverse reactions,dezocine was used safely and effectively for laparoscopic cholecystectomy visceral pain,and it is an ideal analgesic drug.