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2-羟甲基-4-甲氧基-3,5-二甲基吡啶的合成 被引量:1

The Synthesis of 2-hydroxymethyl-4-methoxy-3,5-dimethylpyridine
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摘要 以2,3,5-三甲吡啶为原料,经N-氧化、硝化、甲氧基取代、乙酰化、水解五步反应合成2-羟甲基-4-甲氧基-3,5- 二甲基吡啶,总收率达69.7%. 2-hydroxymethyl-4-methoxy-3, 5-dimethylpyridine, an intermediate of Omprazole and Esomprazole, was synthesized from 2,3,5-trimethylpyridine by N-oxidation, nitration, and methoxy-lation to give the 4-methoxy-3, 5-dimethylpyridine-N-oxide, which was then treated with acetic anhydride and followed by hydrolysis using dilute hydrochloric acid as hydrolytic reagent to give the title compound. The overall yield reached 69. 7% and the method had the advantage of mild reaction, low cost and waste.
出处 《徐州师范大学学报(自然科学版)》 CAS 2003年第1期46-48,共3页 Journal of Xuzhou Normal University(Natural Science Edition)
关键词 2 3 5三甲基吡啶 2-羟甲基-4-甲氧基-3 5-二甲基吡啶 合成 2,3,5-trimethylpyridine 2-hydroxymethyl-4-methoxy-3 ,5-dimethylpyridine synthesis
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  • 1[1]Bell NJV,Burget D,Howden CW,et al.Appropriate acid suppression for the management of gastro-esophageal reflux disease[J].Digestion,1992,51∶S59-S67.
  • 2[2]Rohss K,Lundin C,Rydholm H,et al.Esomeprazole 40 mg provides more effective acid control than omeprazole 40 mg[A].Presented at the XXXIInd Nordic Meeting of Gastroenterology[C].Goteborg,Sweden.2000
  • 3肖国民,吴平东.2,3,5-三甲基吡啶的合成[J].中国医药工业杂志,1997,28(3):144-144. 被引量:2
  • 4康斯坦茨 K,CN 1011969B,1991年
  • 5肖国民,吴平东.2-乙基-3,5-二甲基吡啶的合成[J].化学试剂,1997,19(2):122-123. 被引量:1

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