肠道菌群失调对肝硬化的影响

Influence of intestinal dysbacteriosis on liver cirrhosis

肝硬化是由一种或多种原因引起的、以肝组织弥漫性纤维化、假小叶和再生结节为组织学特征的进行性慢性肝病,一旦进入失代偿期,肝脏和其他多脏器功能受损,几乎无法恢复和逆转。介绍了Toll样受体识别肠道菌群变化从而影响肝硬化及其并发症发生发展的过程。简述了胆汁酸调控肠道菌群对于肝硬化的保护作用。回顾了治疗肠道菌群失调后延缓肝硬化的进展。认为未来针对肠道菌群失调的治疗将会是肝硬化治疗的主要方向。

Liver cirrhosis is a progressive chronic liver disease due to one or more causes,with diffuse fibrosis in liver tissue,pseudolobules,and regenerative nodules as major histological features.Once liver cirrhosis enters the decompensated stage,the liver and several other organs are injured,which can hardly be recovered or reversed.This article introduces the process of Toll-like receptors in recognizing the changes in intestinal flora and the influence of this process on the development and progression of liver cirrhosis,as well as the protective effect of bile acid against liver cirrhosis by regulating intestinal flora.This article also reviews the advances in delaying liver cirrhosis after the treatment of intestinal dysbacteriosis and points out that the treatment of intestinal dysbacteriosis may become the major direction of liver cirrhosis treatment in future.