醒脑静合生脉注射液对急性脑出血肿瘤坏死因子的影响

Efficacy Observation on Influence of Xingnaojing Injection Combined Sheng maiInjection on TNF of Patients with Intracerebral Hemorrhage in Acute Phase

目的观察醒脑静合生脉注射液对急性脑出血患者肿瘤坏死因子(TNF)水平的影响,并初探其作用机制。方法将急性脑出血患者44例随机分为醒脑静组(21例)、醒脑静合生脉组(23例),在西医常观处理基础上分别予醒脑静注射液和醒脑静合生脉注射液,并分别于治疗前后测定外周血TNF水平。结果醒脑静合生脉组血TNF水平较治疗前降低,且其程度优于醒脑静组(P<0.05)。结论抑制急性脑出血的炎症反应,切断血栓形成、自由基反应、缺血损伤的发生发展途径,可能是醒脑静合生脉注射液发挥疗效的途径之一。

Objective:To observe the effect of Xingnaojing Injection combined Shengmai Injection on TNF in patients with intracerebral hemorrhage(ICH) in acute phase,and study the mechanism.Methods:Patients were divided into two groups,A and B. Both were given the routine treatment of WM.Patients in group A were givenXingnaojing Injection,those in group B were given Xingnaojing Injection combined Shenmai Injection in addition.The level of TNF were mesaured before and after treatment.Results:The levels of TNF of patients in group B reduced more remarkably,and the extent was beter than those in group A.Conclusion:It may be one of ways that Xingnaojing Injection combined Shengmai Injection play a curable role to inhibit the inflammatory response of ICH in acute Phase,to cut- off the pathway of deveolpment of thrombosis,free radical reaction and ischemia injury.<P>