血浆C反应蛋白与不稳定型心绞痛危险度分级关系的探讨

The relationship between plasma C-reactive protein and risk classification of unstable angina

目的 :探讨血浆C反应蛋白 (CRP)对不稳定型心绞痛 (UA)危险分层的临床价值。方法 :①测定 112例UA、38例稳定型心绞痛 (SA)及 35例正常对照者的血浆CRP含量 ;②根据Braunwald分级标准将 112例UA按危险度高低分为BraunwaldⅠ级、BraunwaldⅡ级和BraunwaldⅢ级 ,分别比较各级的CRP浓度 ,观察各级在住院期间的恶性室性心律失常、急性心脏病事件 (包括急性心肌梗死、心力衰竭及心源性猝死等 )的发生率。结果 :①UA组的血浆CRP明显高于SA组及对照组 (P <0 .0 5 ) ;②BraunwaldⅠ级、BraunwaldⅡ级和BraunwaldⅢ级的CRP浓度分别为 (5 .2 2± 0 .6 7)mg /L、(6 .0 8± 0 .94 )mg/L及 (6 .95± 1.0 2 )mg/L ,两两比较差异均有显著性意义 (P <0 .0 5 ) ;住院期间恶性室性心律失常及各种心脏病事件的发生率依次递增。结论 :UA患者CRP水平明显升高 ,而且随着危险度分级的增加 ,CRP含量依次增加 ;血浆CRP水平可作为UA患者危险分层的一项参考指标。

Objective:To evaluate the value of plasma C reactive protein (CRP) in risk classification of unstable angina (UA). Methods:The p1asma CRP levels in 112 patients with UA, 38 patients with stable angina (SA) and 30 controls were measured. According to Braunwald classification, the patients with UA were divided into Braunwald Grade Ⅰ, Braunwald Grade Ⅱ and Braunwald Grade Ⅲ on which CRP were compared. The malignant ventricular arrhythmia, cardiovascular events including acute myocardial infarction, heart failure and cardiac death were observed in these three groups during period in the hospital. Results:The plasma CRP levels increased in patients with UA compared with those in patients with SA and the control group (P< 0.05 ). The plasma CRP 1evels in Braunwald Grade Ⅰ ?Braunwald Grade Ⅱ and Braunwald Grade Ⅲ were ( 5.22 ± 0.67 )mg/L?( 6.08 ± 0.94 ) mg / L and ( 6.95 ± 1.02 ) mg/L respectively. There were significant variety between each other (P< 0.05 ). The malignant ventricular arrhythmia and cardiovascular events increased steadily in these three groups. Conclusion:The plasma CRP levels significantly increase in patients with UA. CRP is increasing as the increasing of risk grade. It suggests that the plasma CRP cou1d be seen as an index for the risk classification of UA.