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黄连解毒汤对2型糖尿病大鼠血糖和血脂代谢的影响 被引量:56

Effects of Huang Lian Jie Du Decoction on Blood Glucose and Lipids Metabolisms in Type Ⅱ Diabetic Rats.
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摘要 目的 :探讨黄连解毒汤对实验性 2型糖尿病大鼠的血糖、血脂代谢的影响 ,并探讨其作用机理。方法 :对照观察黄连解毒汤对实验性 2型糖尿病大鼠总胆固醇 (TC)、甘油三酯 (TG)、高密度脂蛋白胆固醇 (HDL C)、载脂蛋白AI(APOAI)、载脂蛋白B(APOB)、口服糖耐量试验 (OGTT)、空腹血糖 (FBG)、血清胰岛素 (INS)、进食及体重的影响。结果 :给予黄连解毒汤干预的 2型糖尿病大鼠 ,其TC、TG、APOB、FBG水平均比模型对照组明显降低 ,而HDL C、APOAI水平显著升高 ,OGTT改善 ,大鼠体重减轻。结论 :黄连解毒汤具有降糖、降脂等作用 ,其作用机理可能与增强胰岛素敏感性及促进胰岛素释放等环节密切相关。 Objective:To study the effects of Huang Lian Jie Du decoction on the blood glucose and lipids metabolism of experimental type 2 diabetic rats and to explore their possible therapeutic mechanism.Method:To Observe the effects of Huang Lian Jie Du decoction on serum total cholesterol (TC),triglycerides (TG), high density lipoprotein cholesterol (HDL C),apolipoprotein A I and B (APOA I,APOB),oral glucose tolerance test (OGTT),fasting blood glucose (FBG) and serum insulin (INS),mean eaten chaw amount and body weight of experimental type 2 diabetic rats.Results:Huang Lian Jie Du decoction could decrease the levels of TC、TG、APOB、FBG and raise the levels of HDL C、APOA I,and improve glucose tolerance and reduce body weight of the rats compared the those in control group.Conclusion:It is suggested that Huang Lian Jie Du decoction would possess the functions of deceasing the levels of blood glucose and lipids and reducing the body weight of experimental rats with type 2 diabetes mellitus,and their therapeutic mechanisms might be closely correlated with their promoting insulin sensitivity and facilitating insulin secretion.
出处 《中国中医基础医学杂志》 CAS CSCD 2003年第4期43-45,共3页 JOURNAL OF BASIC CHINESE MEDICINE
基金 湖北省卫生厅科学基金资助项目 ( 2 0 0 0 13 8)
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