摘要
目的 分析导致高产AmpC酶阴沟肠杆菌感染的临床危险因素。方法 收集阴沟肠杆菌所致的各种临床感染病例 ,头孢西丁三维试验测定各临床病例中分离得到的阴沟肠杆菌的AmpC酶产生情况 ,回顾性比较两组病例在年龄、基础疾病伴发率、细菌学检查前的住院时间及 β 内酰胺类抗生素使用时间、死亡率等方面的差异。结果 在收集到的全部 4 0例阴沟肠杆菌感染病例中 ,由高产AmpC酶阴沟肠杆菌所致者 12例 (30 % ) ,非高产 2 8例 (70 % ) ;高产AmpC酶阴沟肠杆菌感染患者在细菌学检查前使用 β 内酰胺类抗生素的时间为(9.83± 1.93)d ,而非高产AmpC酶组为 (3.10± 0 .78)d ,两者差异非常显著 (P =0 .0 0 0 2 ) ;两组患者在年龄、基础疾病伴发率及细菌学检查前的住院时间方面差异无显著性 (P >0 .0 5 )。结论 较长时间使用 β 内酰胺类抗生素是导致高产Am pC酶阴沟肠杆菌感染的临床主要危险因素。
OBJECTIVE To investigate the clinical factors of Enterobacter cloacae infections with high-level AmpC β-lactamase. METHODS The cases infected by E.cloacae were collected. The patients were divided into two groups: high-level AmpC β-lactamase (HAmpC) and non-high-level AmpC β-lactamase (NHAmpC) according to three-dimensional extracts tests. Compared the difference of age, rate of basic diseases, hospitalization time (HT) and β-lactam antibiotics using time(βAT) before E. cloacae isolated. RESULTS Among 40 cases, 12 (30%) were high-level AmpC β-lactamase E. cloacae infection, 28(70%) were non-high-level AmpC β-lactamase E. cloacae infection. There was a significant difference in βAT between two groups, HAmpC with a mean of 9.83 days and NHAmpC 3.10 days, P=0.0002. There was no difference among age, rate of basic diseases and HT between two groups. CONCLUSIONS β-Lactam antibiotics may contribute to high-level AmpC β-lactamase in E. cloacae infection.
出处
《中华医院感染学杂志》
CAS
CSCD
2003年第6期511-513,共3页
Chinese Journal of Nosocomiology