肉桂酸透皮吸收的实验研究

Experimental study on percutaneous absorption of cinnamic acid

目的 :研究肉桂酸透皮吸收及一些常用助渗剂、pH值对其透皮特性的影响。 方法 :采用K C扩散池进行体外扩散实验 ,选择离体小鼠皮肤为渗透屏障 ,从接收池取样 ,用HPLC检测法测定样品中肉桂酸的含量。结果 :肉桂酸可以透过离体小鼠皮肤 ;其渗透系数随其浓度增加而增加 ;2 0 %乙醇、3 0 %乙醇、3 %氮酮对肉桂酸有显著促渗透作用。结论

Objective: To study percutaneous absorption of cinnamic acid and the effect of some common enhancers and pH value on it. Methods: Drug permeation tests were performed in K-C two-compartment diffusion cell through excised mice skin. Samples were collected from the receiver compartment, cinnamic acid concentration in samples was determined by HPLC. Results: Cinnamic acid could penetrate through excised mice skin. The permeability coefficient of cinnamic acid rose as its concentration increased. Cinnamic acid consisted of 20% ethanol, 30% ethanol and 3% Azone had high penetrating power. Conclusion: The research will provide experimental data for skin administration of Chinese medicine holding cinnamic acid.