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广东省野生动物销售人员SARS冠状病毒抗体血清学研究 被引量:28

Seroprevalence of SARS coronavirus antibody IgG in wild animal traders in Guangdong
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摘要 目的 比较野生动物销售人员和健康人群感染SARS冠状病毒的情况 ,为探索验证SARS冠状病毒源于动物的假设提供依据。方法 于 2 0 0 3年 5月选择广州市 3个野生动物市场销售人员、2家医院的医务人员、某疾病预防控制中心工作人员及某门诊健康体检人员等无SARS临床症状的健康人群为调查对象 ,采集调查对象的血清 ,用间接ELISA法检测SARS冠状病毒IgG抗体。结果 共检测销售野生动物人员血清 5 0 8份 ,SARS冠状病毒抗体阳性率为1 3 0 2 % (6 6 / 5 0 8) ,其中以主要销售果子狸人员的阳性率最高 ,为 72 7% (1 6 / 2 2 ) ,其次销售山猪人员为 5 7 1 % (1 6 / 2 8) ,销售黄犭京人员为 5 6 3% (9/ 1 6 ) ,销售兔人员为 4 6 2 % (6 / 1 3) ,销售山鸡人员为 33 3% (3/ 9) ,另在猫、鸟和蛇等其他 1 2种野生动物的销售人员中均不同程度检出SARS冠状病毒抗体。其他健康人群SARS冠状病毒抗体阳性率为 2 1 1 %(6 / 2 84 ) ,其中医院医务人员为 2 92 % (4 / 1 37) ,疾病控制人员为 1 5 9% (1 / 6 3) ,社区健康人员为 1 1 9% (1 / 84 )。销售野生动物人员SARS冠状病毒抗体阳性率与其他健康人群比较差异有显著性 (χ2 =2 6 0 89,P <0 0 1 )。 Objective Comparing the prevalence of SARS coronavirus ( SARS CoV) antibody IgG in wild animal traders and control groups to provide the evidence for the hypothesis of a wild animal origin for SARS.Methods Serum samples were collected from wild animals traders in 3 animal markets, health care workers (HCWs) in hospital and center for disease control and prevention (CDC) and health control group in Guangzhou. ELISA test for SARS coronavirus antibody IgG with the test kit (batch No.20030501) manufactured in Beijing. Results The positive rate of SARS CoV antibody IgG in wild animal traders was 13.02% (66/508) in wild animal traders. The positive rates in civet cat, wild boar, muntjac, hare, pheasant trader were 72 7%, 57 1%, 56 3%, 46 2%, 33 3% respectively. The antibody were also detected in other animal traders including domestic cats, birds and snakes. The positive rate in hospital and CDC HCWs and health control group were 2 92%, 1 59% and 1 19% respectively. The statistical significance of the positive rate was observed between the wild animal traders and the other control groups ( χ 2 =26 089, P <0 01).Conclusion The results that the positive rate of SARS CoV antibody IgG in wild animal traders significantly higher than that of control groups seem to support the hypothesis of a wild animal origin for SARS.
出处 《华南预防医学》 2003年第3期6-7,共2页 South China Journal of Preventive Medicine
基金 广东省SARS科技攻关项目
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