摘要
AIM: To investigate the effect of hepatitis B virus (HBV)specific immunoglobin (HBIG) and lamivudine on HBV intrauterine transmission in HBsAg positive pregnant women.METHODS: Each subject in the HBIG group (56 cases)was given 200 IU HBIG intramuscularly (im.) every 4weeks from 28-week (wk) of gestation, while each subject in the lamivudine group (43 cases) received 100 mg lamivudine orally (po.) every day from 28-wk of gestation until the 30th day after labor. Subjects in the control group (52 cases) received no specific treatment. Blood specimens were tested for HBsAg, HBeAg, and HBV-DNA in all maternities at 28-wk of gestation, before delivery, and in their newborns 24 hours before the administration of immune prophylaxis.RESULTS: Reductions of HBV DNA in both treatments were significant (P＜0.05). The rate of neonatal intrauterine HBV infection was significantly lower in HBIG group (16.1%)and lamivudine group (16.3 %) compared with control group (32.7 %) (P＜0.05), but there was no significant difference between HBIG group and lamivudine group (P＞0.05). No side effects were found in all the pregnant women or their newborns.CONCLUSION: The risk of HBV intrauterine infection can be effectively reduced by administration of HBIG or Lamivudine in the 3rd trimester of HBsAg positive pregnant women.
AIM:To investigate the effect of hepatitis B virus (HBV) specific immunoglobin (HBIG) and lamivudine on HBV intrauterine transmission in HBsAg positive pregnant women. METHODS:Each subject in the HBIG group (56 cases) was given 200 IU HBIG intramuscularly (im.) every 4 weeks from 28-week (wk) of gestation,while each subject in the lamivudine group (43 cases) received 100 mg lamivudine orally (po.) every day from 28-wk of gestation until the 30^(th) day after labor.Subjects in the control group (52 cases) received no specific treatment.Blood specimens were tested for HBsAg,HBeAg,and HBV-DNA in all maternities at 28-wk of gestation,before delivery,and in their newborns 24 hours before the administration of immune prophylaxis. RESULTS:Reductions of HBV DNA in both treatments were significant (P<0.05).The rate of neonatal intrauterine HBV infection was significantly lower in HBIG group (16.1%) and lamivudine group (16.3%) compared with control group (32.7%) (P<0.05),but there was no significant difference between HBIG group and lamivudine group (P>0.05).No side effects were found in all the pregnant women or their newborns. CONCLUSION:The risk of HBV intrauterine infection can be effectively reduced by administration of HBIG or Lamivudine in the 3^(rd) trimester of HBsAg positive pregnant women.
基金
the Science and Research Foundations of Sun Yat-Sen University
Guangzhou Science Committee,No.1999-J-005-01
