低密度脂蛋白胆固醇与心血管病发病关系的临床研究

Clinical Study of the Relationship between Low-density Lipoprotein Cholesterol and Cardiovascular Disease

目的:研究低密度脂蛋白胆固醇(ox-LDL)水平与心血管病发病的关系。方法:选取422例2016年1月～2017年11月在某院住院治疗的受试者,将其分为观察组(220例)和对照组(202例),采用竞争酶联免疫法(USA)对所有患者的血浆脂联素水平进行检测,采用酶联免疫吸附法(ELISA)法对患者血浆sLDL-C以及低密度脂蛋白胆固醇(ox-LDL)水平进行检测,比较两组受试者脂联素、sLDL-C、ox-LDL水平的关系。结果:观察组血浆脂联素水平低于对照组,但是sLDL-C和ox-LDL水平高于对照组。采用Logistic回归多因素分析结果显示,脂联素水平、sLDL-C以及年龄与心血管疾病的发病情况密切相关;脂联素水平与sLDL-C成负相关,而sLDL-C和ox-LDL呈正相关。结论:心血管疾病患者血浆中的脂联素与sLDL-C呈负性相关,因此,低脂联素水平与高sLDL-C水平是影响心血管疾病患者发病的独立危险因素。

Objective: To study the relationship between the level of low-density lipoprotein cholesterol(ox-LDL) and the incidence of cardiovascular disease. Methods: A total of 422 subjects hospitalized in a hospital from January 2016 to November 2017 were selected and divided into observation group(220 cases) and control group(202 cases). Plasma adiponectin levels were measured in all patients by competitive enzyme-linked immunosorbent assay(USA). Plasma LDL-C and low-density lipoprotein cholesterol(ox-LDL) levels were measured by enzyme-linked immunosorbent assay(ELISA). The relationship between adiponectin, sLDL-C, and ox-LDL levels was compared between the two groups. Results: The plasma adiponectin level was lower in the observation group than in the control group, but the levels of sLDL-C and ox-LDL were higher than those in the control group. Logistic regression multivariate analysis showed that adiponectin levels, sLDL-C, and age were closely related to the incidence of cardiovascular disease;Adiponectin levels were negatively correlated with sLDL-C, whereas sLDL-C and ox-LDL is positively correlated. Conclusion: Plasma adiponectin is negatively correlated with sLDL-C in patients with cardiovascular disease. Therefore, low adiponectin and high sLDL-C levels are independent risk factors for the onset of cardiovascular disease.