青年乳腺癌临床病理特征及分子分型分析

Clinico- pathologic characteristics and molecular phenotypes of breast cancer in young patients

目的:探讨青年乳腺癌临床病理特征及分子分型情况。方法:收集陕西省肿瘤医院2012年1月至2015年6月经手术切除、病理证实的年龄≤35岁的青年乳腺浸润性导管癌病例64例,随机抽取同期年龄>35岁的中老年乳腺浸润性导管癌66例作为对照,回顾性分析其临床病理特征及分子分型情况。结果:青年乳腺癌与中老年乳腺癌在肿瘤大小、病理分期、淋巴结转移及Ki-67表达方面差异有统计学意义(P<0.05),二者分子分型的分布差异无统计学意义(P>0.05)。结论:青年乳腺癌肿瘤体积大,病理分期晚,Ki-67表达指数高,应重视其早期筛查与治疗,其高侵袭转移机制有待进一步研究。

Objective: To investigate the clinico- pathologic characteristics and molecular phenotypes of breast cancer in young patients. Methods: Data from 64 cases of infiltrating ductal carcinoma in young patients( age ≤35years) who underwent surgery between January 2012 and June 2015 were reviewed. 66 cases of infiltrating ductal carcinoma in middle- aged and elderly patients( age > 35 years) during the corresponding period were randomly selected as controls. The clinico- pathologic characteristics and molecular phenotypes were retrospectively analyzed. Results:The young patients of breast cancer significantly different from the middle- aged and elderly patients in terms of tumor size,pathologic stage,lymph node metastasis and the expression of Ki- 67( P < 0. 05). There were no significant differences of the molecular phenotypes between them( P > 0. 05). Conclusion: Young patients of breast cancer have larger size,more lated pathologic stage and higher expression of Ki- 67 compared with the middle- aged and elderly. Early screening and prompt treatment are necessary for young patients of breast cancer. The mechanisms of the strong invasion and metastasis still need further study.