中西医结合治疗老年性多发性骨髓瘤的临床效果观察

Clinical Observation of Combining Traditional Chinese and Western Medicine for Senile Multiple Myeloma

目的对老年性多发性骨髓瘤患者采用中西医结合治疗,观察和分析其治疗的临床效果。方法将68例老年性多发性骨髓瘤患者按照随机数字表法分为对照组和治疗组。对照组:采用VAD方案进行化疗;治疗组:在对照组治疗基础上加用中药治疗。结果经过治疗后,治疗组有效率和不良反应发生率分别为85.29%(29/34)、5.88%(2/34),与对照组67.65%(23/34)、20.59%(7/34)比较,P均<0.05。治疗前后,2组患者的骨髓浆细胞数和M蛋白值均出现明显下降,但与对照组比较,治疗组下降更明显(P<0.05);与治疗前比较,对照组治疗后血红蛋白值和β2微球蛋白值均没有明显的变化(P>0.05),而治疗组则变化明显(P<0.05)。治疗后观察组血红蛋白值和β2微球蛋白值与对照组治疗后比较,P<0.05。结论临床上,采用中西医结合治疗老年性多发性骨髓瘤,能有效地改善患者的临床症状,提高治疗效果,降低不良反应发生率。

Objective To study the clinical efficacy of combine traditional Chinese and western medicine for senile multiple myeloma. Methods 68 cases of senile patients with multiple myeloma were divided into the control group and the treatment group according to random number table method. The control group received VAD chemotherapy treatment; the treatment group received additional traditional Chinese medicine treatment on the basis of control group therapy. Results After treatment,effective rate and adverse reactions rate of the treatment group were 85. 29%( 29 /34) and 5. 88%( 2 /34),and those of the control group were 67. 64%( 23 /34) and 20. 59%( 7 /34)( P < 0. 05); Before and after treatment,the number of plasma cells,bone marrow and M protein values of the 2 groups of patients significantly decreased,but the treatment group was better than that of the control group( P < 0. 05); After treatment,compared with before treatment,hemoglobin values and beta 2 microglobulin of the control group had no significant change( P > 0. 05); hemoglobin values and beta 2 microglobulin of the treatment group compared with before treatment( P < 0. 05),compared with the control group( P < 0. 05). Conclusion Clinically,combined traditional Chinese and western medicine for senile patients with multiple myeloma can effectively improve the patient’s clinical symptoms and treatment effect,and reduce adverse reactions.