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牛磺酸对大鼠酒精性肝损伤保护作用的研究 被引量:17

THE PROTECTIVE EFFECT OF TAURINE ON ALCOHOLIC LIVER DAMAGE IN RAT
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摘要 目的 : 通过观察牛磺酸对大鼠酒精性肝损伤的保护效果 ,为预防及治疗酒精性肝损伤提供理论及实验依据。方法 : 通过白酒灌胃建立大鼠酒精性肝损伤模型 ,治疗组分别给予高低两种剂量的牛磺酸 ,对照组 0 .9%生理盐水 ,实验末测血压、血清甘油三酯 (TG) ,并对大鼠肝脏进行病理及量化分析。结果 : 与模型组相比 ,高低两种浓度的 (2 %和 5 %)牛磺酸均可以显著降低酒精性肝损伤大鼠血清甘油三酯 (P<0 .0 5 ) ;高剂量组牛磺酸还能降低酒精性肝损伤大鼠血压(P<0 .0 5 ) ;肝脏病理切片量化分析显示 ,高低两种剂量牛磺酸均可显著降低酒精对肝脏的损伤 (P<0 .0 5 ) ,且高低剂量组的保护效果无显著性差异 (P>0 .0 5 )。结论 : 牛磺酸能够有效保护酒精对大鼠肝脏的损伤。 Objective: To observe the preventive effect of taurine on alcoholic liver damage in rat.Methods: The model was induced by filling stomach with alcohol, and the treatment groups were given two different concentrations of taurine, and the control group was given 0.9%NS, then we measured the blood triglycerides (TG), and the pathological changes of liver quantitatively.Results: Two different le-vels of taurine can significantly decrease the level of TG and ameliorate the liver damage of rats (P<0.05) as compared with rats who received alcohol only, and the effects of two different concentrations were not significantly different (P>0.05), and the 5% taurine group can also decrease the mean arterial pressure (P<0.05). Conclusion: Taurine can protect liver from alcoholic damage to some extent.
出处 《营养学报》 CAS CSCD 北大核心 2003年第3期290-293,共4页 Acta Nutrimenta Sinica
关键词 酒精性肝损伤 牛磺酸 甘油三酯 血压 taurine alcoholic liver damage rat blood pressure triglycerides quantitative analysis
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