期刊文献+

上海地区女性生殖道人乳头瘤病毒感染的检测 被引量:1

DETECTION OF HUMAN PAPILLOMAVIRUS INFECTION IN GENITAL OF FEMALE PATIENTS OF SHANGHAI AREA
下载PDF
导出
摘要 应用地高辛甙元标记人乳头瘤病毒(HPV)-6,11,16和18探针,通过核酸杂交法检测上海地区女性患者HPV的感染。计活检组织标本128例,阴道脱落细胞130例,同时取样34例。斑点杂交结果表明活检组织中四种类型HPV的总阳性率:宫颈癌44%,宫颈间变66.7%,有间变史28.6%,外阴尖锐湿疣63%和慢性宫颈炎5.6%。阴道脱落细胞的各阳性率与之相近,同时取样的检测符合率为91.2%。Southern转移杂交结果提示:宫颈癌以HPV-16型为主。 Detection of human papillomavirus infection in female patients of the Shanghai area by nucleic acid hybridization uaing digoxigenin labelled HPV-6, 11, 16 and 18 probes was performed on 128 biopsy, 129 exfoliated vaginal cell and 34 both biopsy and exfoliated cell specimens. Positive rates combined HPV-6, 11, 16 and 18 in biopsy specimens of oervicrl carcinoma, cervical dysplasia, past cervical dysplasia, vaginal condylomata and cervitis were 44%, 66.7%, 28.6 %, 63% and 8.6% respectively by spot hybridization. Similar results were obtained on exfoliated cell specimens. In an analysis of 34 patients with both biopsy and exfoliated cell the coincident detection rate was 91.2%. Southern blot hybridization results showed that HPV in cervical carcinoma was mainly type 16, whereas in vaginal condylomata, types 6 and 11.
出处 《上海医科大学学报》 CSCD 1992年第4期289-293,共5页 Journal of Fudan University(Medical Science)
关键词 生殖道 核酸杂交法 乳头状瘤病毒 human papillomavirus genital digoxigenin nucleic acid hybridization
  • 引文网络
  • 相关文献

参考文献2

  • 1孟祥金,中国病毒学,1989年,1期,22页
  • 2韩日才,中华医学杂志,1988年,68卷,7期,387页

同被引文献9

引证文献1

二级引证文献23

;
使用帮助 返回顶部