血清降钙素原检测在经皮肝穿胆道支架植入术后的临床应用观察

The clinical study of serum procalcitonin changes before and after percutaneous transhepatic biliary stent implantation

目的:探讨血清降钙素原(PCT)检测在经皮肝穿胆道支架植入术后的临床应用效果。方法:我科恶性梗阻性黄疸行经皮肝穿胆道支架植入术患者86例,随机分为两组:血清降钙素原检测组(43例)和血清降钙素原未检测组(43例)。血清PCT的测定采用电化学发光法,采用国际标准化的PCT参考品校准仪器,质控结果在控后,进行样本检测。其参考范围为0~0.05ng/ml。结果:血清降钙素原检测组中胆汁培养阳性、胆汁培养G-患者的血清降钙素原检测结果及敏感性明显高于胆汁培养阴性、胆汁培养G+者;血清降钙素原检测组痊愈率比血清降钙素原未检测组高,但显效率低,差异均有统计学意义(P<0.05);两组治疗后进步率、有效率比较,差异均无统计学意义(P>0.05)。结论:血清降钙素原是一个具有较高灵敏性、特异性和稳定性的炎性反应指标,对经皮肝穿胆道支架植入术后指导临床治疗、判断预后具有一定价值,值得在临床中应用。

Objective:To study the changes of serum procalcitonin(PCT)before and after percutaneous transhepatic biliary stent implantation.Methods:Eighty-six patients of malignant obstructive jaundice who were treated by percutaneous transhepatic biliary stent implantation were randomly divided into two groups:serum procalcitonin detecting group and serum procalcitonin non-detecting group.Serum PCT was detected by electrochemical luminescence method,through the PCT reference calibration instrument international standardization,quality control results in control,sample detection.The reference value is less than 0.05ng/ml.Results:The serum levels of bile culture positive,bile culture G-,serum level of serum calcitonin and the sensitivity were significantly higher than those of bile culture negative and bile culture G.The recovery rate was higher than that of the serum level of in serum and the control group,the difference was statistically significant(P <0.05),and the difference was not statistically significant(P >0.05).Conclusion:Serum procalcitonin is a high sensitivity,specificity and stability index of inflammatory reaction,percutaneous transhepatic biliary stent implantation in guiding clinical treatment,prognosis has certain clinical value,worth in clinical application.