色素膜炎的临床特点、发病机制与治疗方法

Analysis of the clinical features,pathogenesis and treatment methods of uveitis

目的:对色素膜炎的临床特点、发病机制与治疗方法进行分析探讨。方法:2012年9月-2013年10月收治色素膜炎患者72例,作为研究对象,将其随机分为观察组和对照组,每组36例,对照组患者采用曲安奈德治疗,观察组在此基础上加用环磷酰胺,观察并比较两组临床疗效以及药物不良反应。结果:观察组总有效率86.1%,显著均优于对照组36.1%,组间比较差异有统计学意义(P<0.05),观察组药物不良反应率16.7%,与对照组13.9%比较,差异无统计学意义(P>0.05)。结论:曲安奈德联合环磷酰胺治疗色素膜炎可有效提高临床疗效,未增加患者不良反应,具有非常积极的临床应用价值。

Objective:To analyze and explore the clinical features,pathogenesis and treatment methods of uveitis.Methods:72cases with uveitis were selected from September 2012 to October 2013.They were as the research objects.They were randomly divided into the observation group and the control group with 36 cases in each.The control group were treated with triamcinolone acetonide.The observation group were treated with cyclophosphamide on this basis.The clinical curative effects and adverse drug reactions of patients in two groups were observed and compared.Results:The total effective rate of the observation group was86.1%.It was significantly better than 36.1% of the control group.The difference between groups was significant(P<0.05).The rate of adverse drug reaction of the observation group(16.7%) was higher than 13.9% of the control group.but the difference was no statistically significant(P>0.05).Conclusion:Triamcinolone acetonide combined with cyclophosphamide in the treatment of uveitis can effectively improve the clinical effect.It not increased adverse reactions.It has very positive clinical application value.