S-100B检测在婴幼儿中枢神经感染诊疗中的应用

Application of S-100B test in the diagnosis and treatment of infants and young children in the central nervous system infection

目的:通过探讨婴幼儿中枢神经感染中S-100B浓度与感染类型及程度的关系,评价血液S-100B变化与预后关系。方法:2012年1月-2013年9月收治中枢神经感染患儿90例,其中化脓性脑膜炎30例,病毒性脑炎50例,结核性脑炎10例。检测不同感染类型的患儿急性期脑脊液S-100B含量;检测不同程度症状患儿检测急性期和恢复期血液S-100B含量。结果:不同程度婴幼儿中枢神经感染中血液S-100B浓度与对照组对比,P<0.01差异有统计学意义。恢复期治疗好转的患儿血液S-100B含量下降明显,P<0.05。S-100B在病毒性脑膜炎组升高最为显著,P<0.05有统计学意义。结论:血液S-100B与神经系统受损的程度有关,其变化可以评估预后。

Objective:Through discussing the relationship between the concentration of S-100 B in infants with CNS infection and the type of infection and the extent,to evaluate the relationship between prognosis and the change of blood S100 B.Methods:90patients with CNS infection were selected from January 2012 to September 2013,30 cases of purulent meningitis,50 cases of viral encephalitisn,10 cases of tuberculous encephalitis.We detected different types of infection in patients with acute stage of S-100 B in cerebrospinal fluid,and different degree of symptoms in patients with acute and convalescent serum S-100 B content.Results:Compared with the control group,different degrees of infants with CNS infection in the blood concentration of S-100 B,P<0.01,and there was statistically significant.The patients with convalescent treatment improved,and the blood S-100 B content decreased significantly,P<0.05.S-100 B in viral meningitis group increased most significantly,P<0.05,and there was statistically significant.Conclusion:Blood S-100 B is related to the degree of the nervous system damage.Its variation can evaluate prognosis.