急性冠脉综合征患者血浆HMGB1水平的变化分析被引量：1

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摘要选择我院2012年6月～2013年6月心内科病房或门诊年龄、性别相似的患者共120例,根据患者症状、体征、辅助检查和病史将确诊的典型ST段抬高急性心肌梗死(AMI)患者,且为发病至入院在12h以内者20例分为A组;非ST段抬高心肌梗死组,发病至入院在12h以内者19例分为B组;不稳定型心绞痛患者21例分为C组;另外稳定型心绞痛患者30例归为D组;对照组为无冠心病心电图证据或病史,无糖尿病史的门诊或入院患者30例.采用抗体竞争酶联免疫吸附(ELISA)测定法测定血清HMGB1水平在急性冠脉综合征各组、稳定型心绞痛及正常对照组的表达变化,并记录4和8w内所有患者的病情转归情况,采用SPSS14.0软件包进行数据的统计学处理,P＜0.05具有统计学意义.结果A组患者中血浆HMGB1水平明显高于B组(6.49±3.37 vs 6.01±2.47,P＜0.01),B组显著高于C组患者(6.01±2.47 vs 4.03±1.96,P＜0.01);C组患者中血浆HMGB1水平明显高于D组(4.03±1.96 vs 3.94±1.03s,P＜0.01);D组患者中血浆HMGB1水平明显高于E组(3.94±1.03 vs 3.15±0.73,P＜0.01);研究结果发现血浆HMGB1水平与急性冠脉综合征病变程度呈正相关,相关系数为0.346,P＜0.05.HMGB1水平高低与急性冠脉综合征冠脉病变的严重程度呈正相关,提示急性冠脉综合征的发生及严重程度与HMGB1水平存在联系.

作者李法权杨超兴钟一鸣钟华平周爱琴

机构地区赣南医学院第一附属医院心内一科

出处《现代诊断与治疗》 CAS 2014年第24期5599-5600,共2页 Modern Diagnosis and Treatment

关键词急性冠脉综合征血浆HMGB1 病情转归

分类号 R541.4 [医药卫生—心血管疾病]

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