曲美他嗪对X综合征冠状动脉血流储备异常患者的疗效研究

Effect of trimetazidine in patients with cardiac X-Syndrome and abnormal coronary flow reserve

目的 :研究曲美他嗪与传统药物相结合对伴冠状动脉血流储备减低心脏X综合征患者的疗效及耐受性。方法 :3 0例心脏X综合征且冠状动脉血流储备减低者接受曲美他嗪 2 0mg ,每天 3次 ,联合 β受体阻滞剂、钙通道阻滞剂或长效的硝酸酯类治疗 ,随访 12周后的临床情况并复查平板运动试验。结果 :用药后胸痛发作次数显著减少 ,由用药前 (2 1± 2 9)次 /d减少为用药后的 (1 2± 1 7)次 /d(P <0 0 5 ) ,平板运动试验阳性患者减少 ,用药前后分别为 3 0例和 15例 (P <0 0 1) ,平板运动试验到达终点时间明显延长 ,由治疗前 (7 7± 0 4)min延长为 (9 0±0 5 )min (P <0 0 1)。结论

Objective To assess the anti anginal efficacy and the acceptability of trimetazidine(TMZ)in combination with conventional treatment in patients with cardiac X Syndrom and abnormal coronary flow reserve(CFR).Methods 30 pataients with cardiac X Syndrom and abnormal CFR were included. TMZ 20 mg tid was combined with any one of the 3 traditional medications including β blocks, Calcium antagonists or long acting nitrates. The clinical presentations and results of treadmill tests after 12 weeks of treament were compared.Results TMZ reduced the number of chest pain [(2 1±2 9) times/day vs (1 2±1 7) times/day, P <0 05], positive treadmill test (30 cases before vs 15 cases after, P <0 01) was significantly decreased The duration of treadmill were much longer [(9 0±0 5) min vs (7 7±0 4) min, P <0 01].Conclusion For patients with caroliac X Syndrom, TMZ combination with existing therapy increases the exercise capacity. The drug is safe and effective.