金纳多治疗急性一氧化碳中毒迟发性脑病

Clinical study of Jinnaduo(金纳多) in treating delayed encephalopathy resulting from acute carbon monoxide poisoning

目的 :探讨金纳多治疗急性一氧化碳中毒迟发性脑病 (DEACMP)的临床疗效及发病机制。方法 :将80例 DEACMP患者随机分为治疗组 4 3例 ,对照组 37例。治疗组用金纳多 70 m g静脉滴注 ,对照组用维脑路通 10 0 0 mg、胞二磷胆碱 5 0 0 m g静脉滴注 ,均连用 2 0 d,监测丙二醛 (MDA)、尿酸 (U A)浓度及血小板凝聚率(PAGT)。结果 :治疗组总有效率 88.4 % ,对照组总有效率 6 7.6 % ,两组疗效有显著性差异 (P<0 .0 5 ) ;治疗组治疗后 MDA、U A浓度较治疗前均明显降低 (P均 <0 .0 5 ) ,对照组均变化不明显 (P均 >0 .0 5 ) ;治疗组治疗后PAGT明显下降 (P<0 .0 1) ,而对照组治疗前后无显著变化 (P>0 .0 5 )。结论 :金纳多治疗 DEACMP疗效高 ,不良反应少 ,值得临床推广。

Objective: To investigate the clinical effect and mechanism of Jinnaduo(金纳多) in treating delayed encephalopathy which is caused by acute carbon monoxide poisoning. Methods: Eighty patients with delayed encephalopathy resulting from acute carbon monoxide poisoning were randomly divided into treatment group and control group. Fortythree patients in treatment group were treated in Jinnaduo 70 mg intravenous drip for 20 days; 37 patients in control group were treated in venoruton 1 000 mg and citicoline 500 mg intravenous drip for 20 days. The concentration of malondialdehyde (MDA), uric acid (UA) and platelet aggregation test (PAGT) were tested. Results: Totally effective rate in treatment group was 88.4 percent; and in control group was 67.6 percent.The treatment effects in two groups had significant difference (P<0.05). The concentrations of MDA and UA in treatment group after treatment were lower than those before treatment (both P<0.05); there was not significant difference in control group (both P>0.05). PAGT in treatment group after treatment was lower than that before treatment (P<0.01); there was not significant difference in control group (P>0.05). Conclusion: Jinnaduo in treating delayed encephalopathy resulting from acute carbon monoxide poisoning has good effect and seldom side effect, which can be used extensively in clinic.