葆宫止血颗粒联合卡前列素氨丁三醇注射液对剖宫产产后出血的防治研究

Prevention and Treatment of Postpartum Hemorrhage after Cesarean Section with BaogongZhixueGranulesCombined with Carboprost Tromethamine Injection

目的分析剖宫产产后出血防治中联用葆宫止血颗粒与卡前列素氨丁三醇注射液的临床价值。方法回顾性分析2017年8月～2018年8月在我院行剖宫产的61例产妇的临床资料,根据治疗方法分为A、B两组。A组32例患者术后应用葆宫止血颗粒与卡前列素氨丁三醇注射液预防产后出血,B组29例仅应用卡前列素氨丁三醇注射液治疗。比较用药前后两组凝血功能(FIB、TT、D-D、APTT),产后出血情况、宫缩与恶露维持时间、子宫底下降速度。结果 A组FIB、D-D、TT、APTT均低于B组,差异有统计学意义(P<0.05);A组产后24 h失血量少于B组[(315.74±63.20)ml vs (463.01±50.43)ml],差异有统计学意义(P<0.05);A组宫缩维持天数短于B组[(1.52±0.47)d vs (3.02±0.54)d],差异有统计学意义(P<0.05);A组产后出血率低于B组,差异有统计学意义(P<0.05);A组子宫底下降速度高于B组,恶露维持天数短于B组,差异有统计学意义(P<0.05)。结论剖宫产产后出血防治中葆宫止血颗粒与卡前列素氨丁三醇注射液联用可改善产妇凝血功能,减少产后24 h出血量,降低产后出血率,加快子宫底下降速度,缩短宫缩时间与恶露维持时间,应用效果较好。

Objective To analyze the clinical value of combined use ofBaogong ZhixueGranulesand Carboprost tromethamine injectionin the prevention and treatment of postpartum hemorrhage in cesarean section.Methods The clinical data of 61 women who underwent cesarean section in our hospital from August 2017 to August 2018 were retrospectively analyzed. According to the treatment methods, they were divided into two groups, A and B. 32 patients in group A were treated with Baogong Zhixue Granules and Carprostol tromethamine injection to prevent postpartum hemorrhage. 29 patients in group B were treated with only carprostol tromethamine injection. The coagulation function(FIB, TT, D-D, APTT) of the two groups before and after treatment, postpartum hemorrhage, uterine contraction and lochia maintenance time, and uterine fundus fall rate. Results The FIB, D-D, TT and APTT in group A were lower than those in group B,the difference was statistically significant(P<0.05). The blood loss in group A was lower than that in group B at 24 hours after birth [(315.74 ±63.20) ml vs(463.01±50.43) ml], the difference was statistically significant(P<0.05);The postpartum hemorrhage rate in group A was lower than that in group B,the difference was statistically significant( P<0.05). The number of days of contraction in group A was shorter than that in group B [(1.52 ±0.47)d vs(3.02±0.54)d], the difference was statistically significant(P<0.05);The descending rate of uterine fundus in group A was higher than that in group B, and the number of days of lochia was shorter than that in group B, the difference was statistically significant(P <0.05). Conclusion Prevention and treatment of postpartum hemorrhage in cesarean section the combination of Baogong Zhixue Granules and Carprostol tromethamine injection can improve maternal coagulation function, reduce postpartum hemorrhage 24 hours, reduce postpartum hemorrhage rate, accelerate uterine bottom rate, and shorten uterine contraction Time and lochia maintain time, and the application effect is better.