期刊文献+

癌胚胎纤维连接蛋白mRNA在甲状腺乳头状癌中的表达

Expression of Oncofetal Fibronectin mRNA in Thyroid Papillary Carcinoma
下载PDF
导出
摘要 目的 探讨癌胚胎纤维连接蛋白mRNA在甲状腺乳头状癌中的表达及其意义。方法 采用RT-PCR技术检测了10例甲状腺乳头状癌,12例腺瘤和9例正常甲状腺组织中的癌胚胎纤维连接蛋白mRNA表达。结果 10例乳头状癌中8例癌胚胎纤维连接蛋白mRNA表达阳性,其他12例腺瘤、9例正常甲状腺表达均为阴性。结论 癌胚胎纤维连接蛋白mRNA在乳头状癌中特异性表达,提示癌胚胎纤维连接蛋白mRNA有可能成为甲状腺乳头状癌的一种分子生物指标,具有一定的潜在性临床应用价值。 Purpose: To investigate expression of oncofetal fibronectin(onFN) mRNA in the thyroid papillary carcinoma. Methods: The expression of oncofetal fibronectin mRNA in 10 thyroid papillary carcinomas, 12 thyroid adnomas, 9 normal thyroid tissues were detected by using reverse transcription polymerase chain reaction(RT-PCR). Results: The oncofetal fibronectin mRNA expressed in 8 of 10 papillary crcinomas, but not in 12 adenomas, 9 normal thyroid tissues. Conclusions: It is suggested that oncofetal fibronectin mRNA, which specially expressed in the thyroid papillary carcinomas, may become a biological marker with potentially clinical value.
出处 《复旦学报(医学版)》 EI CAS CSCD 北大核心 2003年第6期594-595,共2页 Fudan University Journal of Medical Sciences
  • 引文网络
  • 相关文献

参考文献11

  • 1Hidemaitsu M,Koji T,Koiti T.The oncofetal structure of humon fibronectin defined by moncolonal antibody FDC-6.The Journal Acad Soci USA,1985,82:6527
  • 2MandelU,GaggeroB,Reibel J,et al.Oncofetal fibronectirs in oral carcinomas:correlation of differenttypes.APMIS,1994,102:695
  • 3Lortdon-Rosa B,Vielh P,Mattsuura H,et al.Distribution of oncofetal fibronectin in human mammary tumor:immuno-fluorescence study on histological sectiods.Cancer Res,1990,50:1608
  • 4Inufusa H,Nakamurra M,Adachi T,et al.Localization of oncofetal and normal fibronectin in colorectal cancer:correlation with histologic grade,liver metastasis.Canceer(Phila.),1995,75:2802
  • 5David L,Mandel U,Clausen H,et al.Immunohistochemical expression of oncofetal fibronectin in berign and malignant letions of the stomsch.EurJ Carcer,1993,29A:2070
  • 6Ryu S,Jimi S,Takebeyashi S.Thyroid carinoma distinctively expresses intracellular fibronectin in vivo.Carcer Lett,1997,21:189
  • 7Takano T,Furmio M,Hiromi S,et al.Rapid dection of specific messengenger RNAs in thyroid carcinomas by reverse transcnption-PCR withdegenerate primer:specific espression of oncofetal fihronectin messenger RNA papillary carcinoma.Cancer Res,1997,57:3792
  • 8Takano T,Matsuzuka A,Yokozawa T,et al.Restricted expression of oncofetal fibronectin mRNA in thyroid papillary and anaplastic carcinoma:in situ hybridization study.Br J Caycer,1998,78:221
  • 9Minuto F,Barreca A,Del-Monte P,et al.Immunoreactive insulinlike growthfactorI(IGF-I)and IGF-I binding proteinin human thyroidtissue.J Clin Eedocinoll Meta,1989,68:621
  • 10Di-Carlo A,Marioano A,Pissano G,et al.Epidermal growth factor recepter and thyrotropin tresponse in humnan thyroid tissues.J Endocrinol Jnvest,1990,13:293
;
使用帮助 返回顶部