摘要
目的 探讨癌胚胎纤维连接蛋白mRNA在甲状腺乳头状癌中的表达及其意义。方法 采用RT-PCR技术检测了10例甲状腺乳头状癌,12例腺瘤和9例正常甲状腺组织中的癌胚胎纤维连接蛋白mRNA表达。结果 10例乳头状癌中8例癌胚胎纤维连接蛋白mRNA表达阳性,其他12例腺瘤、9例正常甲状腺表达均为阴性。结论 癌胚胎纤维连接蛋白mRNA在乳头状癌中特异性表达,提示癌胚胎纤维连接蛋白mRNA有可能成为甲状腺乳头状癌的一种分子生物指标,具有一定的潜在性临床应用价值。
Purpose: To investigate expression of oncofetal fibronectin(onFN) mRNA in the thyroid papillary carcinoma. Methods: The expression of oncofetal fibronectin mRNA in 10 thyroid papillary carcinomas, 12 thyroid adnomas, 9 normal thyroid tissues were detected by using reverse transcription polymerase chain reaction(RT-PCR). Results: The oncofetal fibronectin mRNA expressed in 8 of 10 papillary crcinomas, but not in 12 adenomas, 9 normal thyroid tissues. Conclusions: It is suggested that oncofetal fibronectin mRNA, which specially expressed in the thyroid papillary carcinomas, may become a biological marker with potentially clinical value.
出处
《复旦学报(医学版)》
EI
CAS
CSCD
北大核心
2003年第6期594-595,共2页
Fudan University Journal of Medical Sciences