基于数据挖掘的张冰教授治疗皮肤瘙痒用药规律研究

Medication rules of Professor Zhang Bing in treatment of skin itching based on data mining

皮肤瘙痒是一种引起搔抓欲望的主观感觉,为皮肤科最常见的临床症状,甚至是皮肤科患者的唯一主诉,严重影响患者的生活质量。该研究通过收集张冰教授治疗皮肤瘙痒处方,基于中医传承辅助平台软件构建数据库,采用关联规则和复杂系统熵聚类等数据挖掘方法,确定处方中各种药物的使用频次及药物之间的关联规则,分析张冰教授治疗皮肤瘙痒的用药经验。共收集处方147首,分析出20个使用频次34及以上的药物、20个高频次药物组合,挖掘出14个核心组合及7首新处方。使用高频次药物为地肤子、白鲜皮、桑白皮等,高频次药物组合为"白鲜皮-地肤子""白芷-川芎""赤芍-白芍"等,核心组合有"荆芥-防风-桂枝""牛蒡子-蝉蜕-鱼腥草""野菊花-地肤子-白鲜皮"等,形成新处方"荆芥、防风、桂枝、威灵仙、刺蒺藜、白鲜皮""黄柏、金银花、苍术、野菊花、地肤子、白鲜皮""牛蒡子、蝉蜕、鱼腥草、瓜蒌"等。结果表明张冰教授治疗皮肤瘙痒用药经验以祛风止痒、清热燥湿为主。

Skin itching is a subjective sensation that causes the desire to scratch. It is one of the most common clinical symptoms at department of dermatology, even the only complaint of dermatological patients, which seriously affects the quality life of patients. Therefore, based on the software of traditional Chinese medicine inheritance auxiliary platform, association rules and complex system entropy clustering were adopted to collect and analyze Zhang Bing′s prescriptions for skin itching, and get the drug use frequency and the relationship between drugs. Based on that, we could conclude the experience for skin itching. A total of 147 prescriptions were collected, 20 drugs with a frequency of 34 or more and 20 high-frequency drug combinations were analyzed, and 14 core combinations and 7 new prescriptions were excavated. The high-frequency drugs included Kochiae Fructus, Dictamni Cortex, Mori Cortex. The high-frequency drug combinations included 'Kochiae Fructus-Dictamni Cortex' 'Angelicae Dahuricae Radix-Chuanxiong Rhizoma' 'Paeoniae Radix Rubra-Paeoniae Radix Alba', and the core combinations included 'Schizonepetae Herba-Saposhnikoviae Radix-Cinnamomi Ramulus' 'Arctii Fructus-Cicadae Periostracum-Houttuyniae Herba' 'Ghrysanthemi Indici Flos-Kochiae Fructus-Dictamni Cortex', and new formulations include 'Schizonepetae Herba, Saposhnikoviae Radix, Cinnamomi Ramulus, Clematidis Radix et Rhizoma, Tribuli Fructus, Dictamni Cortex', 'Phellodendri Chinensis Coritex, Lonicerae Japonicae Flos, Atractylodis Rhizoma, Ghrysanthemi Indici Flos, Kochiae Fructus, Dictamni Cortex' 'Arctii Fructus, Cicadae Periostracum, Houttuyniae Herba, Trichosanthis Fructus'. The result of this research shows that Professor Zhang Bing′s experience in the treatment of skin itching is mainly to dispelling wind and arresting itching, clearing heat and drying dampness.