血清白细胞介素-6对感染相关脓毒症患者病情的评估效果

Effect of serum IL-6 on evaluation of illness condition of patients with infection-related sepsis

目的探讨血清白细胞介素-6(IL-6)对感染相关脓毒症患者病情的评估效果。方法回顾性分析2014年10月-2018年10月于医院住院治疗且行IL-6检测的584例患者临床资料,对疑似感染致脓毒症患者进行快速序贯器官衰竭评分(qSOFA),将qSOFA评分≥2分的83例患者作为研究组,所有研究对象中选择性别、年龄、临床诊断与研究组相匹配的未感染患者83例作为对照组。按照序贯器官衰竭评分(SOFA)评分将研究组患者分为脓毒症患者(SOFA评分≥2分)74例与非脓毒症患者(SOFA评分<2分)9例。74例脓毒症患者根据脓毒症诊断标准分为脓毒症休克患者7例,非脓毒症休克患者67例。比较患者血清IL-6水平在各组之间及不同SOFA评分之间的差异。结果研究组患者血清IL-6水平为[95.3(50.7,222.4)]pg/ml高于对照组[9.8(6.4,18.6)]pg/ml,比较差异有统计学意义(P<0.05);脓毒症患者血清IL-6水平为[90.7(51.3,222.4)]pg/ml高于非脓毒症患者的[20.5(9.2,98.0)]pg/ml(P<0.05);脓毒症休克组患者血清IL-6水平为[2185.9(426.4,4762.6)] pg/ml高于非脓毒症休克组的[87.4(22.5,2012.5)] pg/ml(P<0.05);不同SOFA评分患者血清IL-6水平比较差异无统计学意义。结论血清IL-6水平对于脓毒症的诊断与病情严重程度的评估有重要价值,血清IL-6水平与不同SOFA评分之间无相关性。

OBJECTIVE To explore the effect of serum interleukin-6(IL-6)on evaluation of illness condition of patients with infection-related sepsis.METHODS The clinical data of 584 patients who were hospitalized for treatment and received IL-6 test from Oct 2014 to Oct 2018 were retrospectively analyzed,the Sepsis-related Organ Failure Assessment(SOFA)scoring,the diagnostic criteria for sepsis,was performed for the patients who were suspected for infection-induced sepsis,83 patients whose qSOFA score was no less than 2 points were assigned as the study group,and 83 patients without infection who had matched gender,age and clinical diagnosis with the patients of the study group were picked from all of the study objects and set as the control group.The patients in the study group were divided into the sepsis group with 74 cases(SOFA score no less than 2 points)and the non-sepsis group with 9 cases(SOFA score less than 2 points).The 74 sepsis patients were divided into the septic shock patients with 7 cases and the non-septic shock patients with 67 cases according to the diagnostic criteria for sepsis.The serum IL-6 level was compared among the groups and the patients with different scores.RESULTS The serum IL-6 level of the study group was[95.3(50.7,222.4)]pg/ml,significantly higher than[9.8(6.4,18.6)]pg/ml of the control group(P<0.05).The serum IL-6 level of the sepsis patients was[90.7(51.3,222.4)]pg/ml,significantly higher than[20.5(9.2,98.0)]pg/ml of the non-sepsis group(P<0.05).The serum IL-6 level of the septic shock patients was[2185.9(426.4,4762.6)]pg/ml,significantly higher than[87.4(22.5,2012.5)]pg/ml of the non-septic shock patients(P<0.05).There was no significant difference in the serum IL-6 level among the patients with different SOFA scores.CONCLUSION The serum IL-6 has significant value in diagnosis of sepsis and evaluation of severity of disease,and there is no correlation between the serum IL-6 level and the SOFA score.