摘要
慢性阻塞性肺疾病(COPD)是一种常见的呼吸系统疾病,不仅发病率高,且致残率和致死率也同样居高不下,同时COPD会伴有肺动脉高压、肺纤维化、慢性肺源性心脏病、右心衰竭等多种常见的严重并发症,种种根由都为患者家庭产生严重的经济负担。气道重塑在COPD的发病过程中有举足轻重的地位,正因为气流受限的进行性发展才诱发COPD的咳、喘、闷等主要症状,因此探讨中医药通过缓解气道重塑来干预COPD的发展进程,具有极高的研究价值。研究显示,多条信号通路的介导都会诱发气道重塑的进行性加重,且中医药的治疗作用也被实验研究频频证实,中医药常通过多靶点,多通路的介导来达成对COPD的治疗作用。本文主要包含中医药对COPD气道重塑有干预作用的5条信号通路的研究内容,即基质金属蛋白酶(MMPs)/金属蛋白酶组织抑制剂(TIMPs),转化生长因子-β1(TGF-β1)/Smads,Ras同源基因家族成员A/Rho相关的卷曲螺旋激酶(RhoA/ROCK),血管内皮生长因子(VEGF)/碱性成纤维细胞生长因子(b-FGF),核转录因子(NF)-κB。将通过对这5条为研究者所重视的信号通路的研究进展做简要的评述,并对其他或可涉及的信号通路做一定的讨论,冀之为今后的实验研究提供参考和思路。
Chronic obstructive pulmonary disease(COPD)is a common respiratory disease with a high morbidity,disability and mortality.At the same time,COPD is always accompanied by pulmonary hypertension,pulmonary fibrosis,chronic pulmonary heart disease,right heart failure and other common serious complications.All of these cause serious financial burden for the family of patients.Airway remodeling plays an important role in the pathogenesis of COPD.It is the progressive development of airflow restriction that induces the main symptoms of COPD,such as cough,asthma and depression.Therefore,it is of great research value to explore the intervention of traditional Chinese medicine(TCM)in the development of COPD by alleviating airway remodeling.Studies have shown that multiple signaling pathways can induce progressive airway remodeling,and the therapeutic effect of TCM has been frequently confirmed by experimental studies.TCM often has a therapeutic effect on COPD through multitarget and multi-channel mediation.This paper mainly includes five signaling pathways that traditional Chinese medicine can intervene COPD airway remodeling,namely matrix metalloproteinases(MMPs)/tissue inhibitors of metalloproteinase(TIMPs),transforming growth factor(TGF)-beta 1/Smads,RhoA/Rho-associated kinase(ROCK),vascular endothelial growth factor(VEGF)/b-fibroblast growth factor(b-FGF)and nuclear factor(NF)-κB.This paper briefly reviews the research progress of these five signaling pathways,and discusses other signaling pathways that may be involved,in order to provide reference and ideas for future experimental research.
作者
谢文英
包永生
王俊月
尚立芝
王肖艳
李亮
张良芝
包海燕
宋倩红
XIE Wen-ying;BAO Yong-sheng;WANG Jun-yue;SHANG Li-zhi;WANG Xiao-yan;LI Liang;ZHANG Liang-zhi;BAO Hai-yan;SONG Qian-hong(Henan University of Chinese Medicine,Zhengzhou 450046,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2019年第23期1-8,共8页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金面上项目(81573881)
河南省科技攻关项目(182102311163)
关键词
中医药
慢性阻塞性肺疾病
气道重塑
信号通路
研究进展
traditional Chinese medicine
chronic obstructive pulmonary disease
airway remodeling
signaling pathway
research progress