葆宫止血颗粒用于产后出血的临床观察

Clinical Observation of Baogong Zhixue Granules for Postpartum Hemorrhage

目的:探讨葆宫止血颗粒用于产后出血的临床效果。方法:选择分娩的女性患者194例,按照随机数字的方法分为对照组和观察组,每组97例患者,对照组在胎儿娩出之后立刻给予米索前列醇片,观察组在对照组治疗方法基础上给予葆宫止血颗粒,对两组的产后失血情况,恶露持续时间,子宫复原情况,血清纤维蛋白原和D-二聚体浓度变化情况,不良反应情况进行比较。结果:对照组的产后2 h失血量[(335.76±28.69)mL VS.(281.25±26.71)mL],产后24 h失血量[(468.69±54.21)mL VS.(400.08±41.36)mL],恶露持续时间[(20.38±2.76)d VS.(15.64±2.03)d]和产后出血发生率[7.22%(7/97)VS. 0.00%(0/97)]均高于观察组,数据差异均具有统计学意义(t=13.696,9.910,13.626,χ~2=5.335,P<0.05),经过治疗后,对照组的子宫下降幅度从(2.31±0.62)cm升高到(4.59±0.91)cm,FIB从(4.69±0.71)g/mL降低到(4.51±0.43)g/mL,D-二聚体从(3.31±0.32)mg/L降低到(3.02±0.22)mg/L,观察组的子宫下降幅度从(2.35±0.71)cm升高到(6.71±1.12)cm,FIB从(4.73±0.82)g/mL降低到(3.42±0.41)g/mL,D-二聚体从(3.29±0.41)mg/L降低到(1.23±0.21)mg/L,观察组的变化幅度大于对照组,数据差异均具有统计学意义(t=-14.469,18.069,57.965,P<0.05),对照组发生寒战[8.25%(8/97)VS. 1.03%(1/97)],恶心呕吐[11.34%(11/97)VS. 2.06%(2/97)],便秘的比例[10.31%(10/97)VS. 2.06%(2/97)]均高于观察组,数据差异均具有统计学意义(χ~2=4.195,6.678,5.685,P<0.05)。结论:使用葆宫止血颗粒治疗产妇,可以改善阴道出血和子宫内膜修复情况,提升安全性,值得在临床工作中推广。

Objective:To explore the clinical effect of Baogong Zhixue Granules for postpartum hemorrhage.Methods:A total of 194 female patients in our hospital between July 2017 and March 2018 were randomly divided into control group and observation group,with 97 patients in each group.Patients in the control group were given Misoprostol Tablets immediately after delivery,while patients in the observation group were given Baogong Zhixue Granules on the basis of the treatment methods in the control group.The postpartum hemorrhage,lochia duration,uterine recovery,serum fibrinogen and D-dimer concentrations were compared between the two groups.Adverse reactions were compared.Results:The 2 h postpartum blood in the control group[(335.76±28.69)mL VS.(281.25±26.71)mL],24 hours postpartum blood loss[(468.69±54.21)mL VS.(400.08±41.36)mL],duration of lochia[(20.38±2.76)d VS.(15.64±2.03)d]and the incidence of postpartum hemorrhage[7.22%(7/97)vs.0.00%(0/97)]were higher than those in the observation group,and the data was statistically different(t=13.696,9.910,13.626,χ~2=5.335,P<0.05).After treatment,the uterus decline in the control group increased from(2.31±0.62)cm to(4.59±0.91)cm,and FIB decreased from(4.69±0.71)g/mL to(4.51±0.43)g/mL,D-The dimer was reduced from(3.31±0.32)mg/L to(3.02±0.22)mg/L.The uterus decline in the observation group increased from(2.35±0.71)cm to(6.71±1.12)cm,and FIB decreased from(4.73±0.82)g/mL to(3.42±0.41)g/mL,D-dimer reduced from(3.29±0.41)mg/L to(1.23±0.21)mg/L.The magnitude of change in the observation group was greater than that in the control group,and the data was statistically significant(t=-14.469,18.069,57.965,P<0.05).In the control group,chills occurred[8.25%(8/97)vs.1.03%(1/97)],nausea and vomiting[11.34%(11/97)vs.2.06%(2/97)]and the proportion of constipation[10.31%(10/97)VS.2.06%(2/97)]were higher than those of the observation group,and the data was statistically significant(χ~2=4.195,6.678,5.685,P<0.05).Conclusion:Baogong Zhixue Granule can improve vaginal bleeding and endometrial repair and enhance safety,and is worthy of popularizing in clinical work.