探讨卵巢高反应全胚冷冻患者首次冻融胚胎移植时间对妊娠结局的影响

Effects of first freeze-thaw embryo transfer time on pregnancy outcomes in patients with ovarian hyperreactive and whole embryo freezing

目的探讨因卵巢高反应全胚冷冻患者首次冻融胚胎移植时间对妊娠结局的影响。方法回顾性分析2016年12月至2018年6月在我院生殖医学科因卵巢高反应全胚冷冻患者首次行冻胚移植(FET)的381个周期。并根据首次冻融胚胎移植日与取卵日间隔时间不同分为两组:近期组(间隔时间≤50天)和非近期组(间隔时间>50天)。比较两组患者的一般情况、FET周期临床资料、FET周期妊娠结局。结果 1、两组患者的一般情况及FET周期临床资料:年龄、不孕年限、体重指数(BMI)、基础FSH、基础LH、AMH、移植日内膜厚度、移植胚胎数、不同内膜准备方案构成比,差异无统计学意义(P>0.05)。2、两组患者妊娠结局:生化妊娠率、临床妊娠率、胚胎种植率、自然流产率、异位妊娠率,差异无统计学意义(P>0.05)。结论因卵巢高反应行全胚冷冻患者首次冻融胚胎移植时间的选择,对助孕妊娠结局无明显影响。可考虑在取卵周期后首次月经来潮周期,选择合适的冻胚移植方案,尽快行冻胚移植。

Objective:To explore the effects of first freeze-thaw embryo transfer time on pregnancy outcomes in patients with ovarian hyperreactive and whole embryo freezing.Methods:The clinical datas of 381 first FET cycles patients with ovarian hyperreactive and whole embryo freezing in our center from December 2016 to June 2018 were retrospectively analyzed.The cycles were divided into two groups according to the interval between oocyte retrieval and subsequent FET:Adjacent group(interval≤50 d)and No-adjacent group(interval>50 d).The general information,FET clinical datas and FET pregnancy outcomes were compared between the two groups.Results:1.The general information,FET clinical datas of the two group patients:There were no significant differences in ages,duration of infertility,BMI,basic FSH,basic LH,AMH,the number of transplanted embryos,endometrial thickness on the day of embryo transfer,different endometrial preparation constituent ratio(P>0.05)2.The pregnancy outcomes of the two group patients:There were no significant differences in biochemical pregnancy rates,linical pregnancy rates,implantation rates,Spontaneous pregnancy rates,ectopic pregnancy rates(P>0.05).Conclusions:The choice of the time of first freeze-thaw embryo transfer in patients undergoing whole embryo freezing due to high ovarian response had no significant effects on the outcome of assisted pregnancy.During the first menstruation period after the ovum collection period,a suitable frozen embryo transplantation scheme can be selected and the frozen embryo transplantation can be carried out as soon as possible.