摘要
应用水负荷附加抗利尿激素,复制水中毒模型。当水负荷增加兔体重10%后,体感诱发电位(SEP)成份P7、N9、P12和N15峰值潜伏期随体重增加而逐渐延长。体重增加10%及15%时,P12和N15成份振幅均增大,但当增加体重15%以上时,两成份振幅减小或消失。水负荷后SEP峰间潜伏期的延长以P12—N15最显著。各种程度水负荷时,P7和N9的振幅均无显著变化。结果说明,水负荷增加体重10%后,可使神经元的传导发生延缓及皮层神经元兴奋性改变;不同程度的水负荷对神经元兴奋性的影响并不相同,此外水负荷对大脑皮层功能的影响较低位脑干严重。
SEP was recorded when right median nerve was stimulated before and after water load. Increasing body weight above 10% by water load, peak latencies of P7, N9, P12 and N15 were prolonged. Increasing body weight by 25% and above 15%, interpeak latencies of N9-P12 and P12-N15 were prolonged, and the later was more significant.Increasing body weight by 10% and 15%, amplitudes of P12 and N15 were enhanced. But increasing body weight above 15%, amplitudes of P12 and N15 were depressed. There were no significant changes in amplitudes of P7 and N9 in any degree of water load.These results indicated that after water load, impulse conduction along with somatosensory pathway was delayed; the nervous excitability of cerebral cortex was altered; and the dysfunction of the cerebral cortex was more serious than that of the brain-stem.
出处
《中国病理生理杂志》
CAS
CSCD
北大核心
1992年第1期59-63,共5页
Chinese Journal of Pathophysiology
关键词
水中毒
诱发电位
躯体感觉
Water intoxication
Evoked potentials, somatosensory