哮喘患者Sβ_2-MG测定及其临床意义

Determination of serum β_2—micorglobulin and its climical significance in patients with asthma

对31例哮喘患者进行Sβ_2—MG测定,结果显示:哮喘组Sβ_2—MG含量高于正常对照组(P<0.01),且发作时高于缓解时(P<0.01),哮喘第Ⅲ期高于第Ⅲ期(P<0.05)。哮喘并心功能不全组较正常对照组Sβ_2—MG 明显升高(P<0.01),且与心衰程度呈正相关。本文认为Sβ_2—MG含量变化对哮喘病情的判断、预后的估计以及疗效观察都有一定意义。

Serum β_2-microglobulin(Sβ_2—MG)was deter-mined in 31 patients with asthma.The result showed thatSβ_2—MG in asthma group was higher than that in thenormal controls(P<0.01).Patients during asthmaticattack had a higher Sβ_2—MG than these during remission(P<0.01).Patients in the 3rd phase of asthma also hada higher Sβ_2—MG than the 2nd phase(P<0.05).Sβ_2—MG in patients with asthma complicated with cardiacdysfunction was significantly higher than in the normalcontrols(P<0.01);Sβ_2—MG was postively correlatedwith the degree of cardiac dysfunction.We consider thatchange of Sβ_2—MG is of significance in evaluating theseriousness,prognosis and treatment of asthma.