去氢表雄酮硫酸酯钠盐对大鼠子宫及其雌激素受体的影响

Effects of Dehydroepiandrosterone Sulfate on the Uterus and Estrogen Receptors in Rats

<正> 去氢表雄酮硫酸酯钠盐(DHA-S)作为宫颈熟化剂已应用于临床,治疗子宫颈管成熟不全,减少过期产和缩短产程~[1]。我国产科临床也已开始试用。其结构式见下。 妊娠家兔静脉注射DHA-S后,宫颈胶原酶活性增高,胶原纤维分解断裂~[2]。幼大鼠和妊娠末期大鼠注射DHA-S后,子宫、宫颈重量及其含水量都相应有所增加,对照药物雌激素也具有上述作用~[3.4].产妇用药后,血浆和宫颈组织内雌二醇水平均明显增高~[5]。

Dehydroepiandrosterone sulfate (DHA-S) at dosages of 50, 100 and 200 mg/kg s.c. for 3 days was shown to have obvious promotive effects on the growth of the uterus in immature rats. However, DHA-S given to ovariec-tomized rats at 40 and 100 mg/kg for 5 days was found to have no effect on the uterus. Incubation of granulosa cells for 3 h with DHA-S caused a significant increase in estradiol secretion. Even though DHA-S was found to increase uterine estrogen receptor concentration, this compound was shown to have no affinity for the estrogen receptor.It appears that the effects of DHA-S resulted mainly from the activity of its metabolite-estrogen.