摘要
目的 :通过检测Shh(SonicHedgehog)在大鼠牙胚发育不同时期的表达 ,探讨其在牙齿发育过程中的作用。方法 :采用免疫组化方法 ,观察大鼠牙齿发育各阶段标本中Shh的表达。结果 :大鼠牙齿发育早期 ,Shh表达于口腔上皮和牙上皮 ;帽状期表达于成釉器 ;钟状期 ,成釉细胞和成牙本质细胞表达阳性。结论 :Shh在牙齿发育过程中的表达有时空特异性 。
Objective:To investigate the expression of Shh during rat teeth development.Method:We applied immunohistochemical techniques to examine the expression of Shh in rat teeth development at different stage. Result: Shh was expressed in all stage of tooth germ. Immunostaining for shh was detected in dental epithelium , oral epithelium, and ameloblasts. Shh was weakly expressed in odontoblasts.Conclusion: The expression of Shh has spatio-temporal characters, it may play a role in enamel and dentin formation.
出处
《临床口腔医学杂志》
2004年第4期203-204,共2页
Journal of Clinical Stomatology
基金
全军十五计划重点课题基金资助 (0 1Z0 89)