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Shh在大鼠牙胚发育过程中的表达 被引量:5

The expression of Shh during rat teeth development
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摘要 目的 :通过检测Shh(SonicHedgehog)在大鼠牙胚发育不同时期的表达 ,探讨其在牙齿发育过程中的作用。方法 :采用免疫组化方法 ,观察大鼠牙齿发育各阶段标本中Shh的表达。结果 :大鼠牙齿发育早期 ,Shh表达于口腔上皮和牙上皮 ;帽状期表达于成釉器 ;钟状期 ,成釉细胞和成牙本质细胞表达阳性。结论 :Shh在牙齿发育过程中的表达有时空特异性 。 Objective:To investigate the expression of Shh during rat teeth development.Method:We applied immunohistochemical techniques to examine the expression of Shh in rat teeth development at different stage. Result: Shh was expressed in all stage of tooth germ. Immunostaining for shh was detected in dental epithelium , oral epithelium, and ameloblasts. Shh was weakly expressed in odontoblasts.Conclusion: The expression of Shh has spatio-temporal characters, it may play a role in enamel and dentin formation.
出处 《临床口腔医学杂志》 2004年第4期203-204,共2页 Journal of Clinical Stomatology
基金 全军十五计划重点课题基金资助 (0 1Z0 89)
关键词 Sonic HEDGEHOG 大鼠 牙胚发育 免疫组化 Sonic Hedgehog rat teeth development immunohistochemistry
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  • 1Jernvall J;Aberg T;Kettunen P.The life history of an embryonic signaling center:BMP-4 induces p21 and is associated with apoptosis in the mouse tooth enamel knot,1998.
  • 2Hammerschmidt M;Brook A;McMahon AP.The world according to hedgehog[J],1997(1).
  • 3Dassule HR;Lewis P;Bei M.Sonic hedgehog regulates growth and morphogenesis of the tooth[J],2000.
  • 4Hardcastle Z;Hui CC;Sharpe PT.The Shh signalling pathway in early tooth development[J],1999(45).
  • 5Motoyama J;Heng H;Crackower MA.Overlapping and non-overlapping Ptch2 expression with Shh during mouse embryogenesis[J],1998.
  • 6Pelton RW;Dickinson ME;Moses HL.In situ hybridization analysis of TGF beta 3 RNA expression during mouse development:comparative studies with TGF beta 1 and beta 2,1990.
  • 7Jernvall J;Thesleff I.Retune of lost structure in the developmental control of tooth shape,2000.
  • 8Yu CC;Woods AL;Levision DA.The assessment of cellular proliferation by immunohistochemistry: a review of currently available methods and their applications[J],1992.
  • 9Jernvall J;Thesleff I.Reiterative signaling and patterning during mammalian tooth morphogenesis[J],2000.
  • 10Fraidenraich D;Iwahori A;Rudnicki M.Activation of fgf4 gene expression in the myotomes is regulated by myogenic bHLH factors and by sonic hedgehog[J],2000.

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